Artículo
IL-8/IL-17 gene variations and the susceptibility to severe viral bronchiolitis
Pinto, L.A.; De Azeredo Leitão, L.A.; Mocellin, M.; Acosta, Patricio Leandro
; Caballero, Mauricio Tomás; Libster, Romina Paula
; Vargas, J. E.; Polack, F.; Comaru, T.; Stein, R.T.; De Souza, A.P.
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
03/2017
Editorial:
Cambridge University Press
Revista:
Epidemiology and Infection
ISSN:
0950-2688
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Clinical manifestations of acute bronchiolitis (AB) vary from minimal disease to severe respiratory failure. The response to respiratory viral infections is possibly influenced by genetic polymorphisms linked to the regulation of the inflammatory response. In the present study, we investigated whether interleukin-8 (IL-8) and interleukin-17 (IL-17) genetic variants are associated with the severity of AB. A group of Brazilian infants hospitalized with AB and a control group (infants with no or mild AB, without hospitalization) were genotyped for four IL-8/IL-17 variations. For replication, we studied an Argentinean population sample of infants with mild and severe AB. IL-8 polymorphism (rs 2227543) and IL-17 (rs2275913) variants showed significant associations with the severity of AB. The effect of the IL-8 variation could be replicated in the Argentinean sample. This finding suggests that IL-8 variations may influence the severity of AB in young infants. Further genetic association studies in low- or middle-income populations are necessary with the aim of expanding knowledge in this area.
Palabras clave:
Bronchiolitis
,
Interleukin-8
,
Polymorphism
,
Severity
,
Wheezing
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Pinto, L.A.; De Azeredo Leitão, L.A.; Mocellin, M.; Acosta, Patricio Leandro; Caballero, Mauricio Tomás; et al.; IL-8/IL-17 gene variations and the susceptibility to severe viral bronchiolitis; Cambridge University Press; Epidemiology and Infection; 145; 4; 3-2017; 642-646
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