Lamotriginium crotonate and lamotriginium salicylate ethanol monosolvate: The role of solvent molecules in the packing organization

Abstract

Two lamotriginium salts, namely lamotriginium crotonate [systematic name: 3,5- diamino-6-(2,3-dichlorophenyl)-1,2,4-triazin-2-ium but-2-enoate, C9H8Cl2N5 + - C4H5O2 , (III)] and lamotriginium salicylate [systematic name: 3,5-diamino-6- (2,3-dichlorophenyl)-1,2,4-triazin-2-ium 2-hydroxybenzoate ethanol monosolvate, C9H8Cl2N5 + C7H5O3 C2H5OH, (IV)] present extremely similar centrosymmetric hydrogen-bonded A·L·L·A packing building blocks (L is lamotriginium and A is the anion). The fact that salicylate salt (IV) is (ethanol) solvated, while crotonate salt (III) is not, has a profound effect on the way these elemental units aggregate to generate the final crystal structure. Possible reasons for this behaviour are analyzed and the hypothesis raised checked against similar structures in the literature.