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dc.contributor.author
Valva, Pamela
dc.contributor.author
Rios, Daniela Alejandra
dc.contributor.author
Casciato, Paola
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Gadano, Adrián Carlos
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Galdame, Omar
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Mullen, Eduardo
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Bertot, Gustavo
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de Matteo, Elena Noemí
dc.contributor.author
Preciado, María Victoria
dc.date.available
2019-03-26T14:29:44Z
dc.date.issued
2017-12
dc.identifier.citation
Valva, Pamela; Rios, Daniela Alejandra; Casciato, Paola; Gadano, Adrián Carlos; Galdame, Omar; et al.; Nonalcoholic fatty liver disease: Biomarkers as diagnostic tools for liver damage assessment in adult patients from Argentina; Lippincott Williams; European Journal Of Gastroenterology & Hepatology; 30; 6; 12-2017; 637-644
dc.identifier.issn
0954-691X
dc.identifier.uri
http://hdl.handle.net/11336/72512
dc.description.abstract
Background Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has been increasing constantly and linked to the global obesity epidemic. The NAFLD histologic spectrum ranges from simple steatosis to nonalcoholic steatohepatitis (NASH), which can progress to cirrhosis and hepatocellular carcinoma. Liver biopsy is the only reliable means to diagnose and stage NASH, but its invasive nature limits its use. Therefore, the prediction of hepatic injury by means of the development of new noninvasive tests represents a growing medical need. Our aim was to evaluate matrix deposition and cell-death markers, which correlate with liver injury in an NAFLD patient cohort. Patients and methods Liver biopsies and serum from 34 NAFLD adult patients were analyzed. Histological parameters were evaluated. Matrix deposition [hyaluronic acid (HA) and tissue inhibitor of matrix metalloproteinase inhibitor-1 (TIMP-1)] and cell-death markers [cytokeratin-18 (M65) and caspase-cleaved cytokeratin-18 (M30)] were measured in serum samples. Results HA showed an association with fibrosis severity (P=0.03) and M30 with steatosis (P=0.013), inflammation (P=0.004), and fibrosis severity (P=0.04). In contrast, TIMP-1 and M65 showed no association with any histological parameter of liver injury. The evaluation of diagnostic accuracy showed good performance as less invasive markers of significant fibrosis of both HA (area under the receiver operating characteristic curve: 0.928) and M30 (area under the receiver operating characteristic curve: 0.848). Conclusion Biomarkers are essential tools that may provide a quick and accurate diagnosis for patients with life-threatening NAFLD and NASH. HA and M30, together or determined sequentially, have been found to be straightforward tests that may be sufficient to predict significant fibrosis even in a primary care center of an underdeveloped country.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hyaluronic Acid
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M30
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M65
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Nonalcoholic Fatty Liver Disease
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Tissue Inhibitor of Matrix Metalloproteinase Inhibitor-1
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Salud Ocupacional
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Nonalcoholic fatty liver disease: Biomarkers as diagnostic tools for liver damage assessment in adult patients from Argentina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-03-20T13:34:55Z
dc.journal.volume
30
dc.journal.number
6
dc.journal.pagination
637-644
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Valva, Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
dc.description.fil
Fil: Rios, Daniela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
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Fil: Casciato, Paola. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Gadano, Adrián Carlos. Hospital Italiano; Argentina
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Fil: Galdame, Omar. Hospital Italiano; Argentina
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Fil: Mullen, Eduardo. Hospital Italiano; Argentina
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Fil: Bertot, Gustavo. Instituto Universidad de la Fundación "Héctor Barceló"; Argentina
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Fil: de Matteo, Elena Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
dc.description.fil
Fil: Preciado, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
dc.journal.title
European Journal Of Gastroenterology & Hepatology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/pubmed?pmid=29384795
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/MEG.0000000000001079


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