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dc.contributor.author
Venturino, Andres
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dc.date.available
2019-03-25T20:03:08Z
dc.date.issued
2017-05
dc.identifier.citation
Venturino, Andres; Toxicogenomics: New strategies for ecotoxicology studies in autochthonous species I. A glade in the entangled path towards the 'Fingerprint' of environmental impact?; Inderscience Enterprises; International Journal of Environment and Health; 8; 3; 5-2017; 203-212
dc.identifier.issn
1743-4955
dc.identifier.uri
http://hdl.handle.net/11336/72461
dc.description.abstract
The search for early and sensitive biomarkers pointing to toxic effects of contaminants over organisms has led the state-of-the-art to the molecular mechanisms of signalling, target and response. The trial to obtain more specific biomarkers of response to toxicants was, in general, biased by the finding of multiple crosstalks between signalling and the transcription factor regulation on gene expression. Molecular biomarkers of toxicity generally show higher sensitivity and precocity in the response, whereas classical biomarkers such as cholinesterases in organisms exposed to anticholinesterasic agents may show 'inconsistent' responses. The use of non-model aquatic organisms, in general, defies the application of commercially available antibodies and implies the design of primers for gene expression studies from model species sequences. The application of transcriptomics has opened a new way to gene annotation and for the design of adequate molecules as tools for the research in new biomarkers in autochthonous species.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Inderscience Enterprises
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Aquatic Toxicology
dc.subject
Biomarkers
dc.subject
Gene Expression Regulation
dc.subject
Transcriptomics
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Toxicogenomics: New strategies for ecotoxicology studies in autochthonous species I. A glade in the entangled path towards the 'Fingerprint' of environmental impact?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-03-08T16:37:22Z
dc.journal.volume
8
dc.journal.number
3
dc.journal.pagination
203-212
dc.journal.pais
Reino Unido
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dc.description.fil
Fil: Venturino, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Centro de Investigaciones En Toxicología Ambiental y Agrobiotecnología del Comahue. Universidad Nacional del Comahue. Facultad de Cs.agrarias. Centro de Investigaciones En Toxicología Ambiental y Agrobiotecnología del Comahue; Argentina
dc.journal.title
International Journal of Environment and Health
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.inderscience.com/info/inarticle.php?artid=86179
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1504/IJENVH.2017.086179
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