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dc.contributor.author
Maslon, Magdalena M.
dc.contributor.author
Heras, Sara R.
dc.contributor.author
Bellora, Nicolás
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dc.contributor.author
Eyras, Eduardo
dc.contributor.author
Cáceres, Javier F.
dc.date.available
2016-08-18T13:04:34Z
dc.date.issued
2014-05-06
dc.identifier.citation
Maslon, Magdalena M. ; Heras, Sara R.; Bellora, Nicolás; Eyras, Eduardo; Cáceres, Javier F.; The translational landscape of the splicing factor SRSF1 and its role in mitosis; eLife Sciences Publications; eLIFE; 3; 6-5-2014; e02028-e02028
dc.identifier.issn
2050-084X
dc.identifier.uri
http://hdl.handle.net/11336/7225
dc.description.abstract
The shuttling serine/arginine rich (SR) protein SRSF1 (previously known as SF2/ASF) is a splicing regulator that also activates translation in the cytoplasm. In order to dissect the gene network that is translationally regulated by SRSF1, we performed a high-throughput deep sequencing analysis of polysomal fractions in cells overexpressing SRSF1. We identified approximately 1500 mRNAs that are translational targets of SRSF1. These include mRNAs encoding proteins involved in cell cycle regulation, such as spindle, kinetochore, and M phase proteins, which are essential for accurate chromosome segregation. Indeed, we show that translational activity of SRSF1 is required for normal mitotic progression. Furthermore, we found that mRNAs that display alternative splicing changes upon SRSF1 overexpression are also its translational targets, strongly suggesting that SRSF1 couples pre-mRNA splicing and translation. These data provide insights on the complex role of SRSF1 in the control of gene expression at multiple levels and its implications in cancer.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
eLife Sciences Publications
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Biochemistry
dc.subject
Cell Biology
dc.subject
Bioinformatics
dc.subject
Human
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
The translational landscape of the splicing factor SRSF1 and its role in mitosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-07-22T18:53:44Z
dc.journal.volume
3
dc.journal.pagination
e02028-e02028
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Maslon, Magdalena M. . Institute of Genetics and Molecular Medicine, University of Edinburgh; Reino Unido
dc.description.fil
Fil: Heras, Sara R.. Institute of Genetics and Molecular Medicine, University of Edinburgh; Reino Unido. Universidad de Granada; España
dc.description.fil
Fil: Bellora, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Patagonia Norte. Instituto de Investigación En Biodiversidad y Medioambiente; Argentina. Universitat Pompeu Fabra; España
dc.description.fil
Fil: Eyras, Eduardo. Universitat Pompeu Fabra; España. Catalan Institution for Research and Advanced Studies (ICREA),
Barcelona; España
dc.description.fil
Fil: Cáceres, Javier F.. University Of Edinburgh; Reino Unido
dc.journal.title
eLIFE
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.02028
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.7554/eLife.02028
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/content/3/e02028/article-metrics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/24842991
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/content/3/e02028
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