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dc.contributor.author
Wilson Rodriguez, Carlos
dc.contributor.author
Terman, Jonathan R.
dc.contributor.author
González Billault, Christian
dc.contributor.author
Ahmed, Giasuddin
dc.date.available
2019-03-21T20:50:48Z
dc.date.issued
2016-10
dc.identifier.citation
Wilson Rodriguez, Carlos; Terman, Jonathan R.; González Billault, Christian; Ahmed, Giasuddin; Actin filaments-A target for redox regulation; John Wiley and Sons Inc.; Cytoskeleton; 73; 10; 10-2016; 577-595
dc.identifier.issn
1949-3592
dc.identifier.uri
http://hdl.handle.net/11336/72246
dc.description.abstract
Actin and its ability to polymerize into dynamic filaments is critical for the form and function of cells throughout the body. While multiple proteins have been characterized as affecting actin dynamics through noncovalent means, actin and its protein regulators are also susceptible to covalent modifications of their amino acid residues. In this regard, oxidation-reduction (Redox) intermediates have emerged as key modulators of the actin cytoskeleton with multiple different effects on cellular form and function. Here, we review work implicating Redox intermediates in post-translationally altering actin and discuss what is known regarding how these alterations affect the properties of actin. We also focus on two of the best characterized enzymatic sources of these Redox intermediates—the NADPH oxidase NOX and the flavoprotein monooxygenase MICAL—and detail how they have both been identified as altering actin, but share little similarity and employ different means to regulate actin dynamics. Finally, we discuss the role of these enzymes and redox signaling in regulating the actin cytoskeleton in vivo and highlight their importance for neuronal form and function in health and disease. © 2016 Wiley Periodicals, Inc.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley and Sons Inc.
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Actin
dc.subject
Mical
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Nadph Oxidase
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Post-Translational Modification
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Redox
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Actin filaments-A target for redox regulation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-03-21T14:17:33Z
dc.journal.volume
73
dc.journal.number
10
dc.journal.pagination
577-595
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Wilson Rodriguez, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Chile; Chile. Center for Geroscience; Chile
dc.description.fil
Fil: Terman, Jonathan R.. The University of Texas Southwestern; Estados Unidos
dc.description.fil
Fil: González Billault, Christian. Universidad de Chile; Chile. Center for Geroscience; Chile. The Buck Institute for Research on Aging; Estados Unidos
dc.description.fil
Fil: Ahmed, Giasuddin. The University of Texas Southwestern; Estados Unidos
dc.journal.title
Cytoskeleton
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/cm.21315
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1002/cm.21315
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