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dc.contributor.author
Blanco, Federico Carlos  
dc.contributor.author
Soria, Marcelo Abel  
dc.contributor.author
Klepp, Laura Ines  
dc.contributor.author
Bigi, Fabiana  
dc.date.available
2019-03-20T17:57:17Z  
dc.date.issued
2017-11  
dc.identifier.citation
Blanco, Federico Carlos; Soria, Marcelo Abel; Klepp, Laura Ines; Bigi, Fabiana; ERAP1 and PDE8A Are Downregulated in Cattle Protected against Bovine Tuberculosis; Karger; Journal of Molecular Microbiology and Biotechnology; 27; 4; 11-2017; 237-245  
dc.identifier.issn
1464-1801  
dc.identifier.uri
http://hdl.handle.net/11336/72113  
dc.description.abstract
Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M. bovis infection. In this study, we found that ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Karger  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Mycobacterium Bovis  
dc.subject
Transcriptomics  
dc.subject
Cattle  
dc.subject
Immune Response  
dc.subject.classification
Otras Ciencias Biológicas  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
ERAP1 and PDE8A Are Downregulated in Cattle Protected against Bovine Tuberculosis  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-03-20T13:27:22Z  
dc.journal.volume
27  
dc.journal.number
4  
dc.journal.pagination
237-245  
dc.journal.pais
Suiza  
dc.journal.ciudad
Basel  
dc.description.fil
Fil: Blanco, Federico Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina  
dc.description.fil
Fil: Soria, Marcelo Abel. Universidad de Buenos Aires. Facultad de Agronomía; Argentina  
dc.description.fil
Fil: Klepp, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina  
dc.description.fil
Fil: Bigi, Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina  
dc.journal.title
Journal of Molecular Microbiology and Biotechnology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/FullText/479183  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1159/000479183