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dc.contributor.author
Chicco, Adriana Graciela  
dc.contributor.author
Basabe, Juan Carlos  
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Karabatas, Liliana Margarita  
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Ferraris, Norma  
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Fortino, Alejandra  
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Bolzon, Yolanda Ana Rosa  
dc.date.available
2019-03-19T19:56:18Z  
dc.date.issued
2000-10  
dc.identifier.citation
Chicco, Adriana Graciela; Basabe, Juan Carlos; Karabatas, Liliana Margarita; Ferraris, Norma; Fortino, Alejandra; et al.; Troglitazone (CS-045) normalizes hypertriglyceridemia and restores the altered patterns of glucose-stimulated insulin secretion in dyslipidemic rats; W B Saunders Co-Elsevier Inc; Metabolism-clinical And Experimental; 49; 10; 10-2000; 1346-1351  
dc.identifier.issn
0026-0495  
dc.identifier.uri
http://hdl.handle.net/11336/72038  
dc.description.abstract
Rats fed a sucrose-rich diet ([SRD] 63% wt/wt) up to 270 days develop stable hypertriglyceridemia, impaired glucose tolerance, and insulin insensitivity. The aim of the present study is to Investigate whether the hypoglycemic agent troglitazone introduced as a pharmacologic intervention could improve and/or reverse the whole-body insulin insensitivity and related abnormalities present after feeding normal rats with a SRD long-term. For this purpose, male Wistar rats were fed a SRD for 210 days. While half of the animals continued with this diet for up to 270 days, troglitazone (0.2 g/dL wt/wt) was added to the SRD of the other half for up to 270 days. Troglitazone markedly reduced in vivo the hepatic triglyceride secretion rate (TGSR) and enhanced its removal from the circulation, leading to a normalization of plasma triglyceride levels. It also normalized the whole-body peripheral insulin resistance, the glucose homeostasis, and the elevated free fatty acids (FFAs) without detectable changes in plasma insulin levels. The clear alteration of the biphasic pattern of glucose-stimulated insulin secretion in the in vitro perfused β-cell islets of rats fed the SRD long-term (270 days) was also completely normalized when the SRD was supplemented with troglitazone for 2 months. The normalization of the altered patterns of glucose-stimulated insulin secretion, as well as the enhancement of peripheral insulin sensitivity without detectable changes in plasma insulin, might be largely a result of the significant action of troglitazone in the decrease of circulating lipids and enhancement of whole-body glucose metabolism. Copyright (C) 2000 by W.B. Saunders Company.  
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application/pdf  
dc.language.iso
eng  
dc.publisher
W B Saunders Co-Elsevier Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Sucrose Rich Diet  
dc.subject
Troglitazone  
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Hipertriglyceridemia  
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Insulin Resistance  
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Otras Ciencias Biológicas  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Troglitazone (CS-045) normalizes hypertriglyceridemia and restores the altered patterns of glucose-stimulated insulin secretion in dyslipidemic rats  
dc.type
info:eu-repo/semantics/article  
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info:ar-repo/semantics/artículo  
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info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-03-18T19:25:00Z  
dc.journal.volume
49  
dc.journal.number
10  
dc.journal.pagination
1346-1351  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Philadelphia  
dc.description.fil
Fil: Chicco, Adriana Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Universidad Nacional del Litoral; Argentina  
dc.description.fil
Fil: Basabe, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Universidad Nacional del Litoral; Argentina  
dc.description.fil
Fil: Karabatas, Liliana Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Universidad Nacional del Litoral; Argentina  
dc.description.fil
Fil: Ferraris, Norma. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Universidad Nacional del Litoral; Argentina  
dc.description.fil
Fil: Fortino, Alejandra. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Universidad Nacional del Litoral; Argentina  
dc.description.fil
Fil: Bolzon, Yolanda Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Universidad Nacional del Litoral; Argentina  
dc.journal.title
Metabolism-clinical And Experimental  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0026049500192157  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1053/meta.2000.9506