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dc.contributor.author
Berger, María Alejandra
dc.contributor.author
Defagot, María Cristina
dc.contributor.author
Villar, Marcelo Jose
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dc.contributor.author
Antonelli, Marta Cristina
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dc.date.available
2019-03-19T18:46:01Z
dc.date.issued
2001-01
dc.identifier.citation
Berger, María Alejandra; Defagot, María Cristina; Villar, Marcelo Jose; Antonelli, Marta Cristina; D4 dopamine and metabotropic glutamate receptors in cerebral cortex and striatum in rat brain; Springer/Plenum Publishers; Neurochemical Research; 26; 4; 1-2001; 345-352
dc.identifier.issn
0364-3190
dc.identifier.uri
http://hdl.handle.net/11336/72025
dc.description.abstract
The characterization of the functional interactions between the metabotropic glutamate receptors (mGluR) and the dopaminergic (DR) receptors in the corticostriatal projections may provide a possible interpretation of synaptic events in the basal ganglia. It has been suggested that presynaptic D2-type receptor located on glutamatergic corticostriatal neurons regulates the release of glutamate. In a first approach we have studied the cellular distribution of the D4R and the mGluRs in cerebral cortex and striatum employing immunocytochemistry. D4R positive neurons were particularly numerous in medial prefrontal cortex mainly occupying layers II and III. An even distribution was found on small round-shaped neurons in the striatum. Group I mGluR1α-like immunoreactivity (mGluR1α-LI) was found in medial and deep layers of the cerebral cortex while group III mGluR4a labeled more superficial layers; group II mGluR2/3 signal was intense on fine fibers with a punctate appearance. In the striatum, mGluR1α and mGluR2/3 stained mainly fibers while mGluR4a labeled round shaped cell bodies. After lateral ventricular injection of colchicine, an axonal transport and firing activity blocker, D4R labeling significantly increased in cerebral cortex and decreased in the striatum, mGluR1α and mGluR4a signal decreased in cerebral cortex and only mGluR4a signal decreased in the striatum. These results support previous reports indicating a presynaptic localization of D4R in the striatum. In contrast, striatal mGluR1α appears to be a postsynaptic receptor probably synthesized in situ. Our results do not support the hypothesis of a colocalization of D4 receptor and one or more of the metabotropic glutamatergic receptors studied here.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer/Plenum Publishers
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Axonal Transport Impairment
dc.subject
Colchicine Injections
dc.subject
Corticostriatal Projections
dc.subject
Immunocytochemical Localization
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
D4 dopamine and metabotropic glutamate receptors in cerebral cortex and striatum in rat brain
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-03-14T14:23:12Z
dc.journal.volume
26
dc.journal.number
4
dc.journal.pagination
345-352
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Berger, María Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Defagot, María Cristina. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
dc.description.fil
Fil: Villar, Marcelo Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
dc.description.fil
Fil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.journal.title
Neurochemical Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1023/A:1010990812840
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1023/A:1010990812840
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