Artículo
Magnetic resonance imaging of 1H long lived states derived from parahydrogen induced polarization in a clinical system
Fecha de publicación:
01/2016
Editorial:
Academic Press Inc Elsevier Science
Revista:
Journal Of Magnetic Resonance
ISSN:
1090-7807
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Hyperpolarization is a powerful tool to overcome the low sensitivity of nuclear magnetic resonance (NMR). However, applications are limited due to the short lifetime of this non equilibrium spin state caused by relaxation processes. This issue can be addressed by storing hyperpolarization in slowly decaying singlet spin states which was so far mostly demonstrated for non-proton spin pairs, e.g. 13C-13C. Protons hyperpolarized by parahydrogen induced polarization (PHIP) in symmetrical molecules, are very well suited for this strategy because they naturally exhibit a long-lived singlet state. The conversion of the NMR silent singlet spin state to observable magnetization can be achieved by making use of singlet-triplet level anticrossings. In this study, a low-power radiofrequency pulse sequence is used for this purpose, which allows multiple successive singlet-triplet conversions. The generated magnetization is used to record proton images in a clinical magnetic resonance imaging (MRI) system, after 3 min waiting time. Our results may open unprecedented opportunities to use the standard MRI nucleus 1H for e.g. metabolic imaging in the future.
Palabras clave:
Hyperpolarization
,
Long Lived State
,
Parahydrogen
,
Phip
,
Pulse Sequence
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Articulos(IFEG)
Articulos de INST.DE FISICA ENRIQUE GAVIOLA
Articulos de INST.DE FISICA ENRIQUE GAVIOLA
Citación
Graafen, Dirk; Franzoni, Maria Belen; Schreiber, Laura M.; Spiess, Hans W.; Münnemann, Kerstin; Magnetic resonance imaging of 1H long lived states derived from parahydrogen induced polarization in a clinical system; Academic Press Inc Elsevier Science; Journal Of Magnetic Resonance; 262; 1-2016; 68-72
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