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dc.contributor.author
Castro, Gerardo Daniel
dc.contributor.author
Delgado, Aurora Maria
dc.contributor.author
Costantini, Martin Hernan
dc.contributor.author
Castro, Jose Alberto
dc.date.available
2019-03-18T19:55:48Z
dc.date.issued
2001-02
dc.identifier.citation
Castro, Gerardo Daniel; Delgado, Aurora Maria; Costantini, Martin Hernan; Castro, Jose Alberto; Rat ventral prostate xanthine oxidase bioactivation of ethanol to acetaldehyde and 1-hydroxyethyl free radicals: Analysis of its potential role in heavy alcohol drinking tumor-promoting effects; Wiley-liss, Inc; Teratogenesis Carcinogenesis And Mutagenesis; 21; 2; 2-2001; 109-119
dc.identifier.issn
0270-3211
dc.identifier.uri
http://hdl.handle.net/11336/71924
dc.description.abstract
The ability of the ventral prostate cytosolic fractions to biotransform ethanol to acetaldehyde and 1‐hydroxyethyl (1HEt) radicals was tested. Acetaldehyde formation was determined by GC‐FID analysis in the head space of incubation mixtures. 1HEt was determined by spin trapping with PBN followed by extraction, silylation of the adduct and GC‐MS of the product. Prostate cytosol was able to biotransform ethanol to acetaldehyde in the presence of NADH, hypoxanthine, xanthine, caffeine, theobromine, theophylline, and 1,7‐dimethylxanthine but not in the presence of N‐methylnicotinamide. All these biotransformations were inhibited by allopurinol and were sensitive to heating for 5 min at 100°C. The biotransformation of ethanol to acetaldehyde in the presence of purines as cosubstrates was accompanied by the formation of hydroxyl and 1HEt radicals as detected by GC‐MS, and the process was inhibited by allopurinol. Results suggest that prostate cytosolic xanthine oxidase is able to bioactivate ethanol to acetaldehyde and free radicals. The potential of these processes to be involved in tumor‐promoting effects of heavy alcohol drinking in conjunction with high meat and/or purines consumption is analyzed. Multifactorial epidemiological studies considering that possibility might be convenient.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Purines, Alcohol And Prostate Cancer
dc.subject
Purines, Xanthine Oxidase And Prostate Cancer
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Prostatic Ethanol Metabolism
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Ethanol, Acetaldehyde And Prostate
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Ethanol, Free Radicals And Prostate Cancer
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Alcohol, Alcoholism And the Prostate
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Alcohol Biotransformation And Prostate Cancer
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Ethanol Promotion of Prostate Cancer
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Rat ventral prostate xanthine oxidase bioactivation of ethanol to acetaldehyde and 1-hydroxyethyl free radicals: Analysis of its potential role in heavy alcohol drinking tumor-promoting effects
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-03-14T14:21:30Z
dc.journal.volume
21
dc.journal.number
2
dc.journal.pagination
109-119
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Castro, Gerardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
dc.description.fil
Fil: Delgado, Aurora Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
dc.description.fil
Fil: Costantini, Martin Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
dc.description.fil
Fil: Castro, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
dc.journal.title
Teratogenesis Carcinogenesis And Mutagenesis
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/1520-6866(2001)21:2<109::AID-TCM1>3.0.CO;2-4
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/1520-6866%282001%2921%3A2%3C109%3A%3AAID-TCM1%3E3.0.CO%3B2-4


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