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dc.contributor.author
Khan, Zafar U.
dc.contributor.author
Koulen, Peter
dc.contributor.author
Rubinstein, Marcelo
dc.contributor.author
Grandy, David K.
dc.contributor.author
Goldman Rakic, Patricia S.
dc.date.available
2019-03-18T19:48:33Z
dc.date.issued
2001-02
dc.identifier.citation
Khan, Zafar U.; Koulen, Peter; Rubinstein, Marcelo; Grandy, David K.; Goldman Rakic, Patricia S.; An astroglia-linked dopamine D2-receptor action in prefrontal cortex; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 98; 4; 2-2001; 1964-1969
dc.identifier.issn
0027-8424
dc.identifier.uri
http://hdl.handle.net/11336/71919
dc.description.abstract
Typical neuroleptic drugs elicit their antipsychotic effects mainly by acting as antagonists at dopamine D2 receptors. Much of this activity is thought to occur in the cerebral cortex, where D2 receptors are found largely in inhibitory GABAergic neurons. Here we confirm this localization at the electron microscopic level, but additionally show that a subset of cortical interneurons with low or undetectable expression of D2 receptor isoforms are surrounded by astrocytic processes that strongly express D2 receptors. Ligand binding of isolated astrocyte preparations indicate that cortical astroglia account for approximately one-third of the total D2 receptor binding sites in the cortex, a proportion that we found conserved among rodent, monkey, and human tissues. Further, we show that the D2 receptor-specific agonist, quinpirole, can induce Ca(2+) elevation in isolated cortical astrocytes in a pharmacologically reversible manner, thus implicating this receptor in the signaling mechanisms by which astrocytes communicate with each other as well as with neurons. The discovery of D2 receptors in astrocytes with a selective anatomical relationship to interneurons represents a neuron/glia substrate for cortical dopamine action in the adult cerebral cortex and a previously unrecognized site of action for antipsychotic drugs with affinities at the D2 receptor.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
National Academy of Sciences
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Dopamina
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Astroglia
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
An astroglia-linked dopamine D2-receptor action in prefrontal cortex
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-03-14T14:16:09Z
dc.journal.volume
98
dc.journal.number
4
dc.journal.pagination
1964-1969
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington DC
dc.description.fil
Fil: Khan, Zafar U.. University of Yale; Estados Unidos
dc.description.fil
Fil: Koulen, Peter. University of Yale; Estados Unidos
dc.description.fil
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Grandy, David K.. University of Oregon; Estados Unidos
dc.description.fil
Fil: Goldman Rakic, Patricia S.. University of Yale; Estados Unidos
dc.journal.title
Proceedings of the National Academy of Sciences of The United States of America
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29365/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/content/98/4/1964
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1073/pnas.98.4.1964


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Comunidades y colecciones

  • Articulos(INGEBI) [520]
    Articulos de INST.DE INVEST.EN ING.GENETICA Y BIOL.MOLECULAR "DR. HECTOR N TORRES"

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