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dc.contributor.author
Dockstader, Colleen L.
dc.contributor.author
Rubinstein, Marcelo
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dc.contributor.author
Grandy, David K.
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dc.contributor.author
Low, Malcolm J.
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dc.contributor.author
Van Kooy, Derek Der
dc.date.available
2019-03-15T21:31:29Z
dc.date.issued
2001-03
dc.identifier.citation
Dockstader, Colleen L.; Rubinstein, Marcelo; Grandy, David K.; Low, Malcolm J.; Van Kooy, Derek Der; The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice; Wiley Blackwell Publishing, Inc; European Journal Of Neuroscience; 13; 5; 3-2001; 995-1001
dc.identifier.issn
0953-816X
dc.identifier.uri
http://hdl.handle.net/11336/71810
dc.description.abstract
According to the dual systems model for opiate reward, dopamine mediates opiate motivation when an animal is in a deprived motivational state (i.e. opiate-dependent and in withdrawal) and not when an animal is in a nondeprived state (i.e. previously drug-naive). To determine the role of the D2 dopamine receptor subtype in mediating opiate motivation, we examined the behaviour of N5 congenic D2 receptor knockout mice and their wild-type siblings in opiate-naive and opiate-dependent and withdrawn place conditioning paradigms. Opiate-naive D2 receptor knockout mice demonstrated acquisition of morphine-conditioned place preference but failed to acquire place preference when conditioned in the deprived state. We propose that D2 receptor function is critical in mediating the motivational effects of opiates only when the animal is in an opiate-dependent and withdrawn motivational state. These findings also underscore the important influence of the genetic background to a given phenotype, as evidenced by the observation that increasing the allelic contribution from the 129/SvJ strain abolishes morphine place preference in C57BL/6 wild-type mice.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Backcrossing
dc.subject
D2
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Dopamine
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Drug Abuse
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Knockout Mice
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Motivation
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-03-14T14:16:03Z
dc.journal.volume
13
dc.journal.number
5
dc.journal.pagination
995-1001
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Dockstader, Colleen L.. University of Toronto; Canadá
dc.description.fil
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Grandy, David K.. Oregon Health Sciences University; Estados Unidos
dc.description.fil
Fil: Low, Malcolm J.. Oregon Health Sciences University; Estados Unidos
dc.description.fil
Fil: Van Kooy, Derek Der. University of Toronto; Canadá
dc.journal.title
European Journal Of Neuroscience
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1460-9568.2001.01455.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1046/j.1460-9568.2001.01455.x
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