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dc.contributor.author
Antúnez, María Inés
dc.contributor.author
Cardoni, Rita Liliana
dc.date.available
2019-03-14T20:56:43Z
dc.date.issued
2000-02
dc.identifier.citation
Antúnez, María Inés; Cardoni, Rita Liliana; IL-12 and IFN-γ production, and NK cell activity, in acute and chronic experimental Trypanosoma cruzi infections; Elsevier Science; Immunology Letters; 71; 2; 2-2000; 103-109
dc.identifier.issn
0165-2478
dc.identifier.uri
http://hdl.handle.net/11336/71722
dc.description.abstract
Resistance to acute Trypanosoma cruzi infection is mainly associated with a Th1 immune response, characterized by gamma-interferon (IFN-γ) production and activation of macrophages. The outcome of the Th1 response in the spleen and serum of BALB/c and C3H mice infected with T. cruzi, Tulahuen strain was studied. The levels of interleukin-12 p40 (IL-12 p40) and IFN-γ, as well as natural killer (NK) cell cytotoxicity were determined at different time-points during the acute phase, and the production of cytokines was also studied in the chronic infection. At 2 days post-infection (pi), spleen cells from C3H mice increased their NK cell activity and the ex vivo spontaneous release of both IL-12 p40 and IFN-γ. On the other hand, BALB/c mice reached low levels of NK cell cytotoxicity and no IFN-γ production was detected at this time pi, but the cytokine was released at high amounts in the second week of the infection. Seric IL-12 p40 concentrations showed a 3-fold increase in both mouse strains on the second day pi and remained high throughout the acute phase. However, seric IFN-γ levels increased during the late acute infection and were higher in BALB/c than in C3H mice. In chronically infected mice IL-12 p40 was as high as in the acute phase in the serum of both strains, but only BALB/c mice still produced IFN-γ. To the authors' knowledge this is the first report showing the protein levels of IL- 12 p40 determined in vivo in acute and chronic T. cruzi infections. The results reveal differences between both mouse strains in the mechanisms controlling the onset and fate of the Th1 response triggered by the parasite and a long lasting pro-inflammatory stimuli.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Ifn-Γ
dc.subject
Il-12
dc.subject
Nk Cell Activity
dc.subject
T. Cruzi
dc.subject
Th1
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
IL-12 and IFN-γ production, and NK cell activity, in acute and chronic experimental Trypanosoma cruzi infections
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-03-14T14:16:38Z
dc.journal.volume
71
dc.journal.number
2
dc.journal.pagination
103-109
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Antúnez, María Inés. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
dc.description.fil
Fil: Cardoni, Rita Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
dc.journal.title
Immunology Letters
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/S0165-2478(99)00172-8
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165247899001728
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