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dc.contributor.author
Zwirner, Norberto Walter
dc.contributor.author
Marcos, Cintia Y.
dc.contributor.author
Mirbaha, Fariba
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Zou, Yizhou
dc.contributor.author
Stastny, Peter
dc.date.available
2019-03-14T18:26:15Z
dc.date.issued
2000-12
dc.identifier.citation
Zwirner, Norberto Walter; Marcos, Cintia Y.; Mirbaha, Fariba; Zou, Yizhou; Stastny, Peter; Identification of MICA as a new polymorphic alloantigen recognized by antibodies in sera of organ transplant recipients; Elsevier Science Inc; Human Immunology; 61; 9; 12-2000; 917-924
dc.identifier.issn
0198-8859
dc.identifier.uri
http://hdl.handle.net/11336/71659
dc.description.abstract
MHC class I-related chain A (MICA) is an HLA-related, polymorphic gene the product of which may be recognized by a subpopularion of intestinal γδ T cells and may play a role in the activation of a subpopulation of natural killer cells. Using anti-MICA specific rabbit sera we previously demonstrated that freshly isolated monocytes, keratinocytes, fibroblasts, and endothelial cells express MICA. To analyze whether MICA may be a target for specific antibodies in sera of transplanted patients, we produced three recombinant MICA proteins consisting of the α1, α2, and α3 domains, and used them in an enzyme-linked immunosorbent assay. We found that several patients had specific antibodies against MICA. Most of them were detected in serum samples collected at different times after organ rejection. Although this finding raises the question of how these patients became immunized, the fact that the polymorphic, HLA-like MICA molecule, expressed at the cell surface of endothelial cells, is recognized by specific antibodies in sera of transplanted patients, suggests the MICA may be a target molecule in allograft rejection.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Alioantigen
dc.subject
Hla
dc.subject
Mica
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Transplantation
dc.subject.classification
Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Identification of MICA as a new polymorphic alloantigen recognized by antibodies in sera of organ transplant recipients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-03-14T14:17:40Z
dc.journal.volume
61
dc.journal.number
9
dc.journal.pagination
917-924
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Zwirner, Norberto Walter. University of Texas; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Marcos, Cintia Y.. University of Texas; Estados Unidos
dc.description.fil
Fil: Mirbaha, Fariba. University of Texas; Estados Unidos
dc.description.fil
Fil: Zou, Yizhou. University of Texas; Estados Unidos
dc.description.fil
Fil: Stastny, Peter. University of Texas; Estados Unidos
dc.journal.title
Human Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/S0198-8859(00)00162-2
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0198885900001622
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