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dc.contributor.author
Blanco, Sonia B.  
dc.contributor.author
Segura, Elsa Leonor  
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Cura, Estela N.  
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Chuit, Roberto  
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Tulián, Liliana  
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Flores, Isolina  
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Garbarino, Gabriela  
dc.contributor.author
Villalonga, Juan F.  
dc.contributor.author
Gurtler, Ricardo Esteban  
dc.date.available
2019-03-14T16:28:20Z  
dc.date.issued
2000-05  
dc.identifier.citation
Blanco, Sonia B.; Segura, Elsa Leonor; Cura, Estela N.; Chuit, Roberto; Tulián, Liliana; et al.; Congenital transmission of Trypanosoma cruzi: An operational outline for detecting and treating infected infants in northwestern Argentina; Wiley Blackwell Publishing, Inc; Tropical Medicine And International Health; 5; 4; 5-2000; 293-301  
dc.identifier.issn
1360-2276  
dc.identifier.uri
http://hdl.handle.net/11336/71637  
dc.description.abstract
We designed a set of procedures for first-line local health services to detect and treat the congenital transmission of Trypanosoma cruzi at a province-wide scale, and field-tested the programme in the province of Tucumam, northwestern Argentina, from 1992 to 1994. The programme consists of routine screening of pregnant women for seroreactivity to T. cruzi, serological and parasitological follow-up of the newborn at least twice during the first year of age, treatment of the infected infants, and evaluation of the outcome. 927 (5.5%) of 16 842 pregnant women were seroreactive to T. cruzi by indirect haemagglutination assay and ELISA. Twenty-one (6.7%) of 315 newborns to seroreactive mothers were diagnosed as infected with T. cruzi parasites microhaematocrit concentration before 30 days of age. Five newborns who initially tested negative had a T. cruzi infection detected by microhaematocrit and/or serological techniques at 3 or 6 months of age. Thus, congenital infection was diagnosed in 26 (7.1%) infants born to seroreactive women and residing in houses free of triatomine bugs. Four of 6 infants born to seroreactive mothers died during the first year of age and had some evidence of T. cruzi infection; one of the deaths was attributed to T. cruzi based on clinical evidence. After specific treatment with nifurtimox or benznidazole, 30 of 32 infants remained parasitologically and serologically negative. This study shows the feasibility of controlling the incidence of congenitally acquired T. cruzi infections at a province-wide scale by means of a specific screening programme at first-line health services level.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley Blackwell Publishing, Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Benznidazole  
dc.subject
Chagas Disease  
dc.subject
Congenital  
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Control  
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Nifurtimox  
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Serodiag Nosis  
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Transmission  
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Trypanosomiasis  
dc.subject.classification
Epidemiología  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Congenital transmission of Trypanosoma cruzi: An operational outline for detecting and treating infected infants in northwestern Argentina  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-03-14T14:14:03Z  
dc.journal.volume
5  
dc.journal.number
4  
dc.journal.pagination
293-301  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Blanco, Sonia B.. Servicio Nacional de Chagas; Argentina  
dc.description.fil
Fil: Segura, Elsa Leonor. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina  
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Fil: Cura, Estela N.. Centro de Control de Calidad de Biológicos; Argentina  
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Fil: Chuit, Roberto. Secretaría de Salud de la Nación; Argentina  
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Fil: Tulián, Liliana. Servicio Nacional de Chagas; Argentina  
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Fil: Flores, Isolina. Maternidad de Nuestra Señora de la Merced; Argentina  
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Fil: Garbarino, Gabriela. Maternidad de Nuestra Señora de la Merced; Argentina  
dc.description.fil
Fil: Villalonga, Juan F.. Hospital Pediátrico del Niño Jesús; Argentina  
dc.description.fil
Fil: Gurtler, Ricardo Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina  
dc.journal.title
Tropical Medicine And International Health  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1046/j.1365-3156.2000.00548.x  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1046/j.1365-3156.2000.00548.x