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dc.contributor.author
Marzese, Diego Matías
dc.contributor.author
Hoon, Dave S.B.
dc.contributor.author
Chong, Kelly K.
dc.contributor.author
Gago, Francisco E.
dc.contributor.author
Orozco, Javier Dario
dc.contributor.author
Tello, Olga M.
dc.contributor.author
Vargas Roig, Laura Maria
dc.contributor.author
Roque Moreno, Maria
dc.date.available
2019-03-13T19:42:27Z
dc.date.issued
2012-11
dc.identifier.citation
Marzese, Diego Matías; Hoon, Dave S.B.; Chong, Kelly K.; Gago, Francisco E.; Orozco, Javier Dario; et al.; DNA methylation index and methylation profile of invasive ductal breast tumors; American Society of Investigative Pathology; Journal Of Molecular Diagnostics; 14; 6; 11-2012; 613-622
dc.identifier.issn
1525-1578
dc.identifier.uri
http://hdl.handle.net/11336/71523
dc.description.abstract
Breast carcinogenesis is a multistep process that involves both genetic and epigenetic alterations. Identification of aberrantly methylated genes in breast tumors and their relation to clinical parameters can contribute to improved diagnostic, prognostic, and therapeutic decision making. Our objective in the present study was to identify the methylation status of 34 cancer-involved genes in invasive ductal carcinomas (IDC). Each of the 70 IDC cases analyzed had a unique methylation profile. The highest methylation frequency was detected in the WT1 (95.7%) and RASSF1 (71.4%) genes. Hierarchical cluster analysis revealed three clusters with different distribution of the prognostic factors tumor grade, lymph node metastasis, and proliferation rate. Methylation of TP73 was associated with high histological grade and high proliferation rate; methylation of RARB was associated with lymph node metastasis. Concurrent methylation of TP73 and RARB was associated with high histological grade, high proliferation rate, increased tumor size, and lymph node metastasis. Patients with more than six methylated genes had higher rates of relapse events and cancer deaths. In multivariate analysis, TP73 methylation and the methylation index were associated with disease outcome. Our results indicate that methylation index and methylation of TP73 and/or RARB are related to unfavorable prognostic factors in patients with IDC. These epigenetic markers should be validated in further studies to improve breast cancer management. © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society of Investigative Pathology
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Methylation Index
dc.subject
Retinoic Acid Receptor Beta
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Tumor Protein P73
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Breast Cancer
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Medicina Critica y de Emergencia
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Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
DNA methylation index and methylation profile of invasive ductal breast tumors
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-02-06T17:38:22Z
dc.journal.volume
14
dc.journal.number
6
dc.journal.pagination
613-622
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Bethesda
dc.description.fil
Fil: Marzese, Diego Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. Universidad Nacional de Cuyo; Argentina
dc.description.fil
Fil: Hoon, Dave S.B.. Saint John's Health Center; Estados Unidos
dc.description.fil
Fil: Chong, Kelly K.. Saint John's Health Center; Estados Unidos
dc.description.fil
Fil: Gago, Francisco E.. Universidad Nacional de Cuyo; Argentina. Centro Médico de Mendoza; Argentina
dc.description.fil
Fil: Orozco, Javier Dario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo; Argentina. Centro Médico de Mendoza; Argentina
dc.description.fil
Fil: Tello, Olga M.. Universidad Nacional de Cuyo; Argentina
dc.description.fil
Fil: Vargas Roig, Laura Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina
dc.description.fil
Fil: Roque Moreno, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. Universidad Nacional de Cuyo; Argentina
dc.journal.title
Journal Of Molecular Diagnostics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S152515781200178X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.jmoldx.2012.07.001


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