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dc.contributor.author Marzese, Diego Matías
dc.contributor.author Hoon, Dave S.B.
dc.contributor.author Chong, Kelly K.
dc.contributor.author Gago, Francisco E.
dc.contributor.author Orozco, Javier Dario
dc.contributor.author Tello, Olga M.
dc.contributor.author Vargas Roig, Laura Maria
dc.contributor.author Roque Moreno, Maria
dc.date.available 2019-03-13T19:42:27Z
dc.date.issued 2012-11
dc.identifier.citation Marzese, Diego Matías; Hoon, Dave S.B.; Chong, Kelly K.; Gago, Francisco E.; Orozco, Javier Dario; et al.; DNA methylation index and methylation profile of invasive ductal breast tumors; American Society of Investigative Pathology; Journal Of Molecular Diagnostics; 14; 6; 11-2012; 613-622
dc.identifier.issn 1525-1578
dc.identifier.uri http://hdl.handle.net/11336/71523
dc.description.abstract Breast carcinogenesis is a multistep process that involves both genetic and epigenetic alterations. Identification of aberrantly methylated genes in breast tumors and their relation to clinical parameters can contribute to improved diagnostic, prognostic, and therapeutic decision making. Our objective in the present study was to identify the methylation status of 34 cancer-involved genes in invasive ductal carcinomas (IDC). Each of the 70 IDC cases analyzed had a unique methylation profile. The highest methylation frequency was detected in the WT1 (95.7%) and RASSF1 (71.4%) genes. Hierarchical cluster analysis revealed three clusters with different distribution of the prognostic factors tumor grade, lymph node metastasis, and proliferation rate. Methylation of TP73 was associated with high histological grade and high proliferation rate; methylation of RARB was associated with lymph node metastasis. Concurrent methylation of TP73 and RARB was associated with high histological grade, high proliferation rate, increased tumor size, and lymph node metastasis. Patients with more than six methylated genes had higher rates of relapse events and cancer deaths. In multivariate analysis, TP73 methylation and the methylation index were associated with disease outcome. Our results indicate that methylation index and methylation of TP73 and/or RARB are related to unfavorable prognostic factors in patients with IDC. These epigenetic markers should be validated in further studies to improve breast cancer management. © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology.
dc.format application/pdf
dc.language.iso eng
dc.publisher American Society of Investigative Pathology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject METHYLATION INDEX
dc.subject RETINOIC ACID RECEPTOR BETA
dc.subject TUMOR PROTEIN P73
dc.subject BREAST CANCER
dc.subject.classification Medicina Critica y de Emergencia
dc.subject.classification Medicina Clínica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title DNA methylation index and methylation profile of invasive ductal breast tumors
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2019-02-06T17:38:22Z
dc.journal.volume 14
dc.journal.number 6
dc.journal.pagination 613-622
dc.journal.pais Estados Unidos
dc.journal.ciudad Bethesda
dc.description.fil Fil: Marzese, Diego Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. Universidad Nacional de Cuyo; Argentina
dc.description.fil Fil: Hoon, Dave S.B.. Saint John's Health Center; Estados Unidos
dc.description.fil Fil: Chong, Kelly K.. Saint John's Health Center; Estados Unidos
dc.description.fil Fil: Gago, Francisco E.. Universidad Nacional de Cuyo; Argentina. Centro Médico de Mendoza; Argentina
dc.description.fil Fil: Orozco, Javier Dario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo; Argentina. Centro Médico de Mendoza; Argentina
dc.description.fil Fil: Tello, Olga M.. Universidad Nacional de Cuyo; Argentina
dc.description.fil Fil: Vargas Roig, Laura Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo; Argentina
dc.description.fil Fil: Roque Moreno, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. Universidad Nacional de Cuyo; Argentina
dc.journal.title Journal Of Molecular Diagnostics
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S152515781200178X
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.jmoldx.2012.07.001
dc.conicet.fuente individual


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)