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dc.contributor.author
Dib, A.
dc.contributor.author
Palma, Santiago Daniel
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Suárez, G.
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Farías, C.
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Cabrera, P.
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Castro, Silvina Gabriela
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Allemandi, Daniel Alberto
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Moreno, Laura Susana
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Lanusse, Carlos Edmundo
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Sanchez Bruni, Sergio Fabian
dc.date.available
2019-03-13T18:37:00Z
dc.date.issued
2011-04
dc.identifier.citation
Dib, A.; Palma, Santiago Daniel; Suárez, G.; Farías, C.; Cabrera, P.; et al.; Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 34; 2; 4-2011; 136-141
dc.identifier.issn
0140-7783
dc.identifier.uri
http://hdl.handle.net/11336/71503
dc.description.abstract
New therapeutic strategies based on the search of alternative formulations of albendazole (ABZ) and albendazole sulphoxide (ABZSO) are under current development to optimize posology and antiparasite efficacy in dogs. In an incomplete block design, nine dogs were randomly divided into three groups (n=6). Treatments were carried out in two phases as follows. Phase I: Group I (treatment A), animals received ABZ at 25mg/kg of conventional formulation. Group II (treatment B), dogs received 25mg/kg of a modified poloxamer-ABZ formulation. Group III (treatment C), animals were treated with ABZSO in equimolar amount to ABZ doses. After 21days of wash-out period the experiment was repeated (Phase II). Blood samples were collected over 24h and subsequently analysed by high performance liquid chromatography. ABZSO and ABZSO 2 were the analytes recovered in plasma. Significant higher (P<0.001) ABZSO area under the concentration-time curve (+500%) and C max (+487%) values were obtained for the treatment C in comparison with treatments A and B. However, no statistical differences on pharmacokinetic parameters were found between formulations A and B. In conclusion, the enhanced plasma concentration profile obtained for the ABZSO formulation used in treatment C may contribute to optimize the anthelmintic control in dogs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Albendazole
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Dissolution Rate
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Poloxamer
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Solid Dispersions
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Surfactant
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Otras Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-23T18:54:07Z
dc.journal.volume
34
dc.journal.number
2
dc.journal.pagination
136-141
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Dib, A.. Universidad de la República; Uruguay
dc.description.fil
Fil: Palma, Santiago Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Suárez, G.. Universidad de la República; Uruguay
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Fil: Farías, C.. Universidad de la República; Uruguay
dc.description.fil
Fil: Cabrera, P.. Universidad de la República; Uruguay
dc.description.fil
Fil: Castro, Silvina Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Moreno, Laura Susana. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Lanusse, Carlos Edmundo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Sanchez Bruni, Sergio Fabian. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Journal of Veterinary Pharmacology and Therapeutics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1365-2885.2010.01203.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2885.2010.01203.x
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