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dc.contributor.author
Rodrigues, Hosana G.  
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Vinolo, Marco A. R.  
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Sato, Fabio T.  
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Magdalon, Juliana  
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Kuhl, Carolina M. C.  
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Yamagata, Ana S.  
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Pessoa, Ana Flávia M.  
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Malheiros, Gabriella  
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Dos Santos, Marinilce F.  
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Lima, Camila  
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Farsky, Sandra H.  
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Camara, Niels O. S.  
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Williner, María Rosa  
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Bernal, Claudio Adrian  
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Calder, Philip C.  
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Curi, Rui  
dc.date.available
2019-03-11T20:37:20Z  
dc.date.issued
2016-10  
dc.identifier.citation
Rodrigues, Hosana G.; Vinolo, Marco A. R.; Sato, Fabio T.; Magdalon, Juliana; Kuhl, Carolina M. C.; et al.; Oral administration of Linoleic acid induces new vessel formation and improves skin wound healing in diabetic rats; Public Library of Science; Plos One; 11; 10; 10-2016; 1-19; e0165115  
dc.identifier.issn
1932-6203  
dc.identifier.uri
http://hdl.handle.net/11336/71429  
dc.description.abstract
Introduction: Impaired wound healing has been widely reported in diabetes. Linoleic acid (LA) accelerates the skin wound healing process in non-diabetic rats. However, LA has not been tested in diabetic animals. Objectives: We investigated whether oral administration of pure LA improves wound healing in streptozotocin- induced diabetic rats. Methods: Dorsal wounds were induced in streptozotocin-induced type-1 diabetic rats treated or not with LA (0.22 g/kg b.w.) for 10 days. Wound closure was daily assessed for two weeks. Wound tissues were collected at specific time-points and used to measure fatty acid composition, and contents of cytokines, growth factors and eicosanoids. Histological and qPCR analyses were employed to examine the dynamics of cell migration during the healing process. Results: LA reduced the wound area 14 days after wound induction. LA also increased the concentrations of cytokine-induced neutrophil chemotaxis (CINC-2αβ), tumor necrosis factor-α (TNF-α) and leukotriene B4 (LTB4), and reduced the expression of macrophage chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1 (MIP-1). These results together with the histological analysis, which showed accumulation of leukocytes in the wound early in the healing process, indicate that LA brought forward the inflammatory phase and improved wound healing in diabetic rats. Angiogenesis was induced by LA through elevation in tissue content of key mediators of this process: vascular-endothelial growth factor (VEGF) and angiopoietin-2 (ANGPT-2).  
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application/pdf  
dc.language.iso
eng  
dc.publisher
Public Library of Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Oral Administration of Linoleic Acid  
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Skin Wound Healing  
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Diabetic Rats  
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Odontología, Medicina y Cirugía Oral  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Oral administration of Linoleic acid induces new vessel formation and improves skin wound healing in diabetic rats  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-02-27T12:51:05Z  
dc.journal.volume
11  
dc.journal.number
10  
dc.journal.pagination
1-19; e0165115  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
San Francisco  
dc.description.fil
Fil: Rodrigues, Hosana G.. Universidade Estadual de Campinas; Brasil. Universidade de Sao Paulo; Brasil  
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Fil: Vinolo, Marco A. R.. Universidade Estadual de Campinas; Brasil  
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Fil: Sato, Fabio T.. Universidade Estadual de Campinas; Brasil  
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Fil: Magdalon, Juliana. Universidade de Sao Paulo; Brasil  
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Fil: Kuhl, Carolina M. C.. Universidade Estadual de Campinas; Brasil  
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Fil: Yamagata, Ana S.. Universidade de Sao Paulo; Brasil  
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Fil: Pessoa, Ana Flávia M.. Universidade de Sao Paulo; Brasil  
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Fil: Malheiros, Gabriella. Universidade de Sao Paulo; Brasil  
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Fil: Dos Santos, Marinilce F.. Universidade de Sao Paulo; Brasil  
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Fil: Lima, Camila. Universidade de Sao Paulo; Brasil  
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Fil: Farsky, Sandra H.. Universidade de Sao Paulo; Brasil  
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Fil: Camara, Niels O. S.. Universidade de Sao Paulo; Brasil  
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Fil: Williner, María Rosa. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina  
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Fil: Bernal, Claudio Adrian. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
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Fil: Calder, Philip C.. University of Southampton; Reino Unido  
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Fil: Curi, Rui. Universidade de Sao Paulo; Brasil  
dc.journal.title
Plos One  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0165115  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165115