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Artículo

Nematodicidal activity of flubendazole and its reduced metabolite on a murine model of trichinella spiralis infection

Urbizu, Lucia PaolaIcon ; Confalonieri, AlejandraIcon ; Sanchez Bruni, Sergio FabianIcon ; Lanusse, Carlos EdmundoIcon ; Alvarez, Luis IgnacioIcon
Fecha de publicación: 11/2012
Editorial: Karger
Revista: Chemotherapy
ISSN: 0009-3157
Idioma: Inglés
Tipo de recurso: Artículo publicado

Resumen

Background: Flubendazole (FLBZ) is a broad-spectrum benzimidazole anthelmintic compound. The parent FLBZ is metabolized to its reduced (R-FLBZ) and hydrolyzed (H-FLBZ) metabolites. There are no data on the potential nematodicidal activity of R-FLBZ, the main plasma metabolite found in sheep and mice. The goal of the current work was to assess the efficacy of FLBZ and R-FLBZ against Trichinella spiralis in a mouse model. Methods: Both compounds were administered to Balb/c mice infected with T. spiralis as either a cyclodextrin aqueous solution or as a carboxymethylcellulose suspension. Treatments were performed orally (5 mg/kg) at 1 day after infection with T. spiralis. The efficacy of the treatments was assessed at day 6 after infection. Results: While the efficacy obtained for FLBZ and R-FLBZ administered as a solution was 94 and 98%, respectively, the efficacies obtained after the treatment with FLBZ suspensions were 38% (FLBZ) and 64% (R-FLBZ). Conclusion: Under the current experimental conditions, a high nematodicidal efficacy of both FLBZ and R-FLBZ administered as solution preparations was observed.
Palabras clave: Efficacy , Flubendazole , Reduced Flubendazole , Trichinella Spiralis
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/71351
DOI: http://dx.doi.org/10.1159/000342924
URL: https://www.karger.com/Article/Abstract/342924
Colecciones
Articulos(CCT - TANDIL)
Articulos de CTRO CIENTIFICO TECNOLOGICO CONICET - TANDIL
Articulos(CIVETAN)
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Citación
Urbizu, Lucia Paola; Confalonieri, Alejandra; Sanchez Bruni, Sergio Fabian; Lanusse, Carlos Edmundo; Alvarez, Luis Ignacio; Nematodicidal activity of flubendazole and its reduced metabolite on a murine model of trichinella spiralis infection; Karger; Chemotherapy; 58; 4; 11-2012; 295-298
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