We have read with interest the paper from Damle et al analyzing the surface membrane phenotype of B lymphocytes in chronic lymphocytic leukemia (B-CLL). The authors stated that the leukemic cells from all B-CLL patients evaluated (irrespective of immunoglobulin heavy chain (IgVH) gene mutational status) bear the phenotype of antigen-experienced B cells based, among other features, on the very low expression of Fcγ receptors type IIb (FcγRIIb, CD32), which is the main isoform of FcγRII in B lymphocytes.
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Citación:Gamberale, Romina; Geffner, Jorge Raúl; Sanjurjo, Julieta; Fernandez Calloti, Paula X.; Arrosagaray, Guillermo; et al.; Expression of FcRII in chronic lymphocytic leukemia B cells.; American Society of Hematology; Blood; 102; 7; 10-2003; 2698-2699