Highly stereoselective synthesis of steroidal 2,5-diketopiperazines based on isocyanide chemistry

Bruttomesso, Andrea; Eiras, Javier; Ramirez, Javier Alberto; Galagovsky, Lydia Raquel

doi:https://doi.org/10.1016/j.tetlet.2009.03.219

Artículo

Highly stereoselective synthesis of steroidal 2,5-diketopiperazines based on isocyanide chemistry

Bruttomesso, Andrea; Eiras, Javier Icon

; Ramirez, Javier Alberto Icon

; Galagovsky, Lydia Raquel

Fecha de publicación: 07/2009

Editorial: Pergamon-Elsevier Science Ltd

Revista: Tetrahedron Letters

ISSN: 0040-4039

Idioma: Inglés

Tipo de recurso: Artículo publicado

Clasificación temática:

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Resumen

In this Letter we report that the Ugi reaction/cyclization sequence on a steroidal 17-carboxaldehyde leads to novel steroidal 2,5-diketopiperazines with a noteworthy stereoselectivity. A wide variety in the substitution pattern in the heterocyclic moiety was easily achieved by changing the components in the Ugi reaction. © 2009 Elsevier Ltd. All rights reserved.

Palabras clave: 2,5-Diketopiperazines , Heterocyclic Steroids , Multicomponent Reaction , Ugi Reaction

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Licencia

Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)

Identificadores

URI: http://hdl.handle.net/11336/71109

DOI: https://doi.org/10.1016/j.tetlet.2009.03.219

URL: https://www.sciencedirect.com/science/article/pii/S0040403909007886

Colecciones

Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)

Citación

Bruttomesso, Andrea; Eiras, Javier; Ramirez, Javier Alberto; Galagovsky, Lydia Raquel; Highly stereoselective synthesis of steroidal 2,5-diketopiperazines based on isocyanide chemistry; Pergamon-Elsevier Science Ltd; Tetrahedron Letters; 50; 28; 7-2009; 4022-4024

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