Artículo

Synthesis of 4-azasteroids by an intramolecular Ugi reaction

Alonso, FernandoIcon ; Acebedo, Sofía LorenaIcon ; Bruttomesso, Andrea; Ramirez, Javier AlbertoIcon
Fecha de publicación: 11/2008
Editorial: Elsevier Science Inc
Revista: Steroids
ISSN: 0039-128X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

In this paper we report the use of an intramolecular Ugi reaction to synthesize new 4-azacholestanes diversely substituted both at N-4 and C-5. Both the scope and the stereochemical outcome of this approach were studied by varying the nature of the components necessary for this multicomponent reaction. In sight of our results we concluded that this methodology can be applied to obtain 4-azasteroids targeted to find new biologically active compounds.
Palabras clave: 4-AZACHOLESTANES , AZASTEROLS , MULTICOMPONENT REACTION , UGI REACTION
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/71103
DOI: https://dx.doi.org/10.1016/j.steroids.2008.06.002
URL: https://linkinghub.elsevier.com/retrieve/pii/S0039128X08001839
Colecciones
Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Citación
Alonso, Fernando; Acebedo, Sofía Lorena; Bruttomesso, Andrea; Ramirez, Javier Alberto; Synthesis of 4-azasteroids by an intramolecular Ugi reaction; Elsevier Science Inc; Steroids; 73; 12; 11-2008; 1270-1276
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