Syntheses of immunomodulating androstanes and stigmastanes. Comparison of their TNF-alpha inhibitory activity

In a previous work our group showed that some synthetic stigmastanes may play a role in immune-mediated inflammation. In this paper we report the syntheses of a series of new steroidal compounds derived from dehydroepiandrosterone and stigmasterol, and the evaluation of their in vitro inhibitory activity of the TNF-α production by macrophages. A preliminary qualitative structure-activity relationship was established. © 2007 Elsevier Ltd. All rights reserved.

Palabras clave: Androstane , Dhea , Immune Regulation , Steroids , Stigmastane , Tumor Necrosis Factor-Α

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)

Identificadores

URI: http://hdl.handle.net/11336/71093

DOI: https://doi.org/10.1016/j.bmc.2007.09.012

URL: https://www.sciencedirect.com/science/article/pii/S0968089607007870

Colecciones

Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES

Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)

Citación

Ramirez, Javier Alberto; Bruttomesso, Andrea; Michelini, Flavia Mariana; Acebedo, Sofía Lorena; Alche, Laura Edith; et al.; Syntheses of immunomodulating androstanes and stigmastanes. Comparison of their TNF-alpha inhibitory activity; Pergamon-Elsevier Science Ltd; Bioorganic & Medicinal Chemistry; 15; 24; 12-2007; 7538-7544

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