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dc.contributor.author
Malet, Mariana
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dc.contributor.author
Brumovsky, Pablo Rodolfo
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dc.date.available
2019-02-26T17:32:10Z
dc.date.issued
2015-12
dc.identifier.citation
Malet, Mariana; Brumovsky, Pablo Rodolfo; VGLUTs and glutamate synthesis-focus on DRG neurons and pain; MDPI; Biomolecules; 5; 4; 12-2015; 3416-3437
dc.identifier.issn
2218-273X
dc.identifier.uri
http://hdl.handle.net/11336/70860
dc.description.abstract
The amino acid glutamate is the principal excitatory transmitter in the nervous system, including in sensory neurons that convey pain sensation from the periphery to the brain. It is now well established that a family of membrane proteins, termed vesicular glutamate transporters (VGLUTs), serve a critical function in these neurons: they incorporate glutamate into synaptic vesicles. VGLUTs have a central role both under normal neurotransmission and pathological conditions, such as neuropathic or inflammatory pain. In the present short review, we will address VGLUTs in the context of primary afferent neurons. We will focus on the role of VGLUTs in pain triggered by noxious stimuli, peripheral nerve injury, and tissue inflammation, as mostly explored in transgenic mice. The possible interplay between glutamate biosynthesis and VGLUT-dependent packaging in synaptic vesicles, and its potential impact in various pain states will be presented.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Axotomy
dc.subject
Drg
dc.subject
Glutamate
dc.subject
Neuropathy
dc.subject
Neuropeptides
dc.subject
Pain
dc.subject
Peripheral Nerves
dc.subject
Sensory Neurons
dc.subject
Vesicular Glutamate Transporter
dc.subject
Visceral Organs
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
VGLUTs and glutamate synthesis-focus on DRG neurons and pain
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-02-25T13:00:28Z
dc.journal.volume
5
dc.journal.number
4
dc.journal.pagination
3416-3437
dc.journal.pais
Suiza
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dc.journal.ciudad
Basilea
dc.description.fil
Fil: Malet, Mariana. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Investigaciones Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Brumovsky, Pablo Rodolfo. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Investigaciones Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Biomolecules
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/biom5043416
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2218-273X/5/4/3416
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26633536/
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