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dc.contributor.author
Soraci, Alejandro Luis  
dc.contributor.author
Pérez, Denisa Soledad  
dc.contributor.author
Martínez, Guadalupe  
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Amanto, F.  
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Tapia, Maria Ofelia  
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Dieguez, S.  
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Fernández Paggi, María Belén  
dc.date.available
2019-02-26T17:29:04Z  
dc.date.issued
2012-08  
dc.identifier.citation
Soraci, Alejandro Luis; Pérez, Denisa Soledad; Martínez, Guadalupe; Amanto, F.; Tapia, Maria Ofelia; et al.; Fosfomycin concentrations in epithelial lining fluid in weaning piglets; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 35; 4; 8-2012; 406-409  
dc.identifier.issn
0140-7783  
dc.identifier.uri
http://hdl.handle.net/11336/70856  
dc.description.abstract
Concentrations of fosfomycin into the epithelial lining fluid (ELF) were studied by bronchoalveolar lavage (BAL) on 6 healthy weaning piglets after the administration of disodium fosfomycin 15 mg/kg intramuscularly (IM). The mean concentrations of fosfomycin in ELF were lower than those in plasma at all sampling time points. Fosfomycin concentrations in ELF were 12.1 % of those in serum. The degree of penetration of fosfomycin into the ELF was determined by comparing the AUC0–8 in ELF with the AUC0–8 in serum. The ratio AUCELF / AUCserum was 0.15 ± 0.02. The Cmax in serum and in ELF were 45.00 ± 2.51 and 3.10 ± 0.95 µg/ml, respectively. These concentrations were achieved at different times (Tmax in serum and ELF: 1.00 ± 0.00 and 2.58 ± 0.49 h, respectively). Effective bacterial killing can be expected from the first antibiotic dosage when the pathogen’s MIC is covered for at least 60–70% of the dosing interval. Different authors have determined a fosfomycin MIC90 for Streptococcus sp (important respiratory pathogens in piglets) of 0.25 µg/ml. Fosfomycin concentrations in ELF remained above the MIC90 value for Streptococcus during more than 8 h post IM administration of 15 mg/kg in weaning piglets. However, additional studies should be carried out in the lungs of infected pigs.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley Blackwell Publishing, Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Fosfomycin  
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Epithelial Lining Fluid  
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Bronchoalveolar Lavage  
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Weaning Piglets  
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Respiratory Pathogens  
dc.subject.classification
Ciencias Veterinarias  
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Ciencias Veterinarias  
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CIENCIAS AGRÍCOLAS  
dc.title
Fosfomycin concentrations in epithelial lining fluid in weaning piglets  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-01-23T18:55:02Z  
dc.journal.volume
35  
dc.journal.number
4  
dc.journal.pagination
406-409  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Soraci, Alejandro Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Pérez, Denisa Soledad. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Martínez, Guadalupe. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Amanto, F.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Producción Animal; Argentina  
dc.description.fil
Fil: Tapia, Maria Ofelia. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Dieguez, S.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina  
dc.description.fil
Fil: Fernández Paggi, María Belén. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Journal of Veterinary Pharmacology and Therapeutics  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2011.01344.x/abstract  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1365-2885.2011.01344.x