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dc.contributor.author
Soraci, Alejandro Luis

dc.contributor.author
Pérez, Denisa Soledad

dc.contributor.author
Martínez, Guadalupe

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Amanto, F.
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Tapia, Maria Ofelia

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Dieguez, S.
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Fernández Paggi, María Belén

dc.date.available
2019-02-26T17:29:04Z
dc.date.issued
2012-08
dc.identifier.citation
Soraci, Alejandro Luis; Pérez, Denisa Soledad; Martínez, Guadalupe; Amanto, F.; Tapia, Maria Ofelia; et al.; Fosfomycin concentrations in epithelial lining fluid in weaning piglets; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 35; 4; 8-2012; 406-409
dc.identifier.issn
0140-7783
dc.identifier.uri
http://hdl.handle.net/11336/70856
dc.description.abstract
Concentrations of fosfomycin into the epithelial lining fluid (ELF) were studied by bronchoalveolar lavage (BAL) on 6 healthy weaning piglets after the administration of disodium fosfomycin 15 mg/kg intramuscularly (IM). The mean concentrations of fosfomycin in ELF were lower than those in plasma at all sampling time points. Fosfomycin concentrations in ELF were 12.1 % of those in serum. The degree of penetration of fosfomycin into the ELF was determined by comparing the AUC0–8 in ELF with the AUC0–8 in serum. The ratio AUCELF / AUCserum was 0.15 ± 0.02. The Cmax in serum and in ELF were 45.00 ± 2.51 and 3.10 ± 0.95 µg/ml, respectively. These concentrations were achieved at different times (Tmax in serum and ELF: 1.00 ± 0.00 and 2.58 ± 0.49 h, respectively). Effective bacterial killing can be expected from the first antibiotic dosage when the pathogen’s MIC is covered for at least 60–70% of the dosing interval. Different authors have determined a fosfomycin MIC90 for Streptococcus sp (important respiratory pathogens in piglets) of 0.25 µg/ml. Fosfomycin concentrations in ELF remained above the MIC90 value for Streptococcus during more than 8 h post IM administration of 15 mg/kg in weaning piglets. However, additional studies should be carried out in the lungs of infected pigs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc

dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Fosfomycin
dc.subject
Epithelial Lining Fluid
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Bronchoalveolar Lavage
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Weaning Piglets
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Respiratory Pathogens
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Ciencias Veterinarias

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Ciencias Veterinarias

dc.subject.classification
CIENCIAS AGRÍCOLAS

dc.title
Fosfomycin concentrations in epithelial lining fluid in weaning piglets
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-23T18:55:02Z
dc.journal.volume
35
dc.journal.number
4
dc.journal.pagination
406-409
dc.journal.pais
Reino Unido

dc.journal.ciudad
Londres
dc.description.fil
Fil: Soraci, Alejandro Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Pérez, Denisa Soledad. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Martínez, Guadalupe. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Amanto, F.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Producción Animal; Argentina
dc.description.fil
Fil: Tapia, Maria Ofelia. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Dieguez, S.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina
dc.description.fil
Fil: Fernández Paggi, María Belén. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Journal of Veterinary Pharmacology and Therapeutics

dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2011.01344.x/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1365-2885.2011.01344.x
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