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dc.contributor.author
Toutain, P. L.
dc.contributor.author
Modric, S.
dc.contributor.author
Bousquet Mélou, A.
dc.contributor.author
Sallovitz, Juan Manuel
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dc.contributor.author
Lanusse, Carlos Edmundo
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dc.date.available
2019-02-25T17:42:15Z
dc.date.issued
2012-04
dc.identifier.citation
Toutain, P. L.; Modric, S.; Bousquet Mélou, A.; Sallovitz, Juan Manuel; Lanusse, Carlos Edmundo; Should licking behavior be considered in the bioavailability evaluation of transdermal products?; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 35; SUPPL. 1; 4-2012; 39-43
dc.identifier.issn
0140-7783
dc.identifier.uri
http://hdl.handle.net/11336/70783
dc.description.abstract
Antiparasitic drugs, and especially macrocyclic lactones (MLs), are often formulated as pour-on products because of their ease of administration, convenience, and reduction of stress in treated animals. However, because of self- and allo-grooming, much of a drug administered transdermally may be systemically absorbed via the oral route, creating highly variable pharmacokinetic and pharmacodynamic response in treated (and untreated) animals. Testing bioequivalence (BE) of pour-on drugs in cattle under laboratory conditions (with restricted licking) ignores a major factor of drug disposition of these drugs and thus fails to predict therapeutic equivalence in the target population under clinical conditions of use. Therefore, the interanimal and intra-animal variability associated with licking behavior should be considered as a biological fact, rather than a noise that needs to be reduced or eliminated. As a result, it is recommended that the BE testing for pour-on products in cattle be conducted by evaluating both the mean and distribution of bioavailability parameters between the reference and test products when animals are not prevented from allo- and self-licking.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Licking Behaviour
dc.subject
Moxidectin
dc.subject
Bovine
dc.subject
Percutaneous Absorption
dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
Should licking behavior be considered in the bioavailability evaluation of transdermal products?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-23T18:53:27Z
dc.journal.volume
35
dc.journal.number
SUPPL. 1
dc.journal.pagination
39-43
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Toutain, P. L.. Institut National de la Recherche Agronomique; Francia. Université de Toulouse; Francia
dc.description.fil
Fil: Modric, S.. Food and Drug Administration; Estados Unidos
dc.description.fil
Fil: Bousquet Mélou, A.. Institut National de la Recherche Agronomique; Francia. Université de Toulouse; Francia
dc.description.fil
Fil: Sallovitz, Juan Manuel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Lanusse, Carlos Edmundo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Journal of Veterinary Pharmacology and Therapeutics
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1365-2885.2012.01380.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2885.2012.01380.x
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