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dc.contributor.author
Cassolato, Juliana E. F.
dc.contributor.author
Noseda, Miguel D.
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Pujol, Carlos Alberto
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Pellizzari, Franciane M.
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Damonte, Elsa Beatriz
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Duarte, Maria E. R.
dc.date.available
2019-02-22T15:52:50Z
dc.date.issued
2008-12
dc.identifier.citation
Cassolato, Juliana E. F.; Noseda, Miguel D.; Pujol, Carlos Alberto; Pellizzari, Franciane M.; Damonte, Elsa Beatriz; et al.; Chemical structure and antiviral activity of the sulfated heterorhamnan isolated from the green seaweed Gayralia oxysperma; Elsevier; Carbohydrate Research; 343; 18; 12-2008; 3085-3095
dc.identifier.issn
0008-6215
dc.identifier.uri
http://hdl.handle.net/11336/70702
dc.description.abstract
A homogeneous sulfated heterorhamnan was obtained by aqueous extraction, then by ultrafiltration from the green seaweed Gayralia oxysperma. Besides α-l-rhamnose it contains glucuronic and galacturonic acids, xylose and glucose. The structure was established by methylation analyses of the carboxyl-reduced, carboxyl-reduced/desulfated, carboxyl-reduced/Smith-degraded, and carboxyl-reduced/Smith-degraded/desulfated products and 1D, 2D NMR spectroscopy analyses. The heterorhamnan backbone is constituted by 3- and 2-linked rhamnosyl units (1.00:0.80), the latter being ∼50% substituted at C-3 by side chains containing 2-sulfated glucuronic and galacturonic acids and xylosyl units. The 3- and 2-linked rhamnosyl units are unsulfated (20%), disulfated (16%), and mostly monosulfated at C-2 (27%) and C-4 (37%). The branched and sulfated heterorhamnan had high and specific activity against herpes simplex virus.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Antiviral Activity
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Chemical Structure
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Gayralia Oxysperma
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Green Seaweed
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Sulfated Heterorhamnan
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Ulvales
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Chemical structure and antiviral activity of the sulfated heterorhamnan isolated from the green seaweed Gayralia oxysperma
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-02-12T17:10:22Z
dc.journal.volume
343
dc.journal.number
18
dc.journal.pagination
3085-3095
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Cassolato, Juliana E. F.. Universidade Federal do Paraná; Brasil
dc.description.fil
Fil: Noseda, Miguel D.. Universidade Federal do Paraná; Brasil
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Fil: Pujol, Carlos Alberto. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Pellizzari, Franciane M.. Universidade Federal do Paraná; Brasil
dc.description.fil
Fil: Damonte, Elsa Beatriz. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Duarte, Maria E. R.. Universidade Federal do Paraná; Brasil
dc.journal.title
Carbohydrate Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.carres.2008.09.014
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0008621508004564
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