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dc.contributor.author Lee, Bridgin G.
dc.contributor.author Anastasia Gonzalez, Agustin
dc.contributor.author Hempstead, Barbara L.
dc.contributor.author Lee, Francis S.
dc.contributor.author Blendy, Julie A.
dc.date.available 2019-02-21T19:03:26Z
dc.date.issued 2015-12
dc.identifier.citation Lee, Bridgin G.; Anastasia Gonzalez, Agustin; Hempstead, Barbara L.; Lee, Francis S.; Blendy, Julie A.; Effects of the BDNF Val66Met polymorphism on anxiety-like behavior following nicotine withdrawal in mice; Oxford University Press; Nicotine And Tobacco Research; 17; 12; 12-2015; 1428-1435
dc.identifier.issn 1462-2203
dc.identifier.uri http://hdl.handle.net/11336/70638
dc.description.abstract Introduction: Nicotine withdrawal is characterized by both affective and cognitive symptoms. Identifying genetic polymorphisms that could affect the symptoms associated with nicotine withdrawal are important in predicting withdrawal sensitivity and identifying personalized cessation therapies. In the current study we used a mouse model of a non-synonymous single nucleotide polymorphism in the translated region of the brain-derived neurotrophic factor (BDNF) gene that substitutes a valine (Val) for a methionine (Met) amino acid (Val66Met) to examine the relationship between the Val66Met single nucleotide polymorphism and nicotine dependence. Methods: This study measured proBDNF and the BDNF prodomain levels following nicotine and nicotine withdrawal and examined a mouse model of a common polymorphism in this protein (BDNFMet/Met) in three behavioral paradigms: Novelty-induced hypophagia, marble burying, and the open-field test. Results: Using the BDNF knock-in mouse containing the BDNF Val66Met polymorphism we found: (1) blunted anxiety-like behavior in BDNFMet/Met mice following withdrawal in three behavioral paradigms: Novelty-induced hypophagia, marble burying, and the open-field test; (2) the anxiolytic effects of chronic nicotine are absent in BDNFMet/Met mice; and (3) an increase in BDNF prodomain in BDNFMet/Met mice following nicotine withdrawal. Conclusions: Our study is the first to examine the effect of the BDNF Val66Met polymorphism on the affective symptoms of withdrawal from nicotine in mice. In these mice, a single-nucleotide polymorphism in the translated region of the BDNF gene can result in a blunted withdrawal, as measured by decreased anxiety-like behavior. The significant increase in the BDNF prodomain in BDNFMet/Met mice following nicotine cessation suggests a possible role of this ligand in the circuitry remodeling after withdrawal.
dc.format application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject BDNF
dc.subject Val66Met
dc.subject Nicotine
dc.subject Anxiety
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Effects of the BDNF Val66Met polymorphism on anxiety-like behavior following nicotine withdrawal in mice
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2019-02-21T14:54:05Z
dc.journal.volume 17
dc.journal.number 12
dc.journal.pagination 1428-1435
dc.journal.pais Reino Unido
dc.journal.ciudad Oxford
dc.conicet.avisoEditorial This is a pre-copyedited, author-produced version of an article accepted for publication in Nicotine & Tobacco Research following peer review. The version of record Lee, Bridgin G.; Anastasia Gonzalez, Agustin; Hempstead, Barbara L.; Lee, Francis S.; Blendy, Julie A.; Effects of the BDNF Val66Met polymorphism on anxiety-like behavior following nicotine withdrawal in mice; Oxford University Press; Nicotine And Tobacco Research; 17; 12; 12-2015; 1428-1435 is available online at: https://doi.org/10.1093/ntr/ntv047
dc.description.fil Fil: Lee, Bridgin G.. The Pennsylvania State University; Estados Unidos
dc.description.fil Fil: Anastasia Gonzalez, Agustin. Cornell University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil Fil: Hempstead, Barbara L.. Cornell University; Estados Unidos
dc.description.fil Fil: Lee, Francis S.. Cornell University; Estados Unidos
dc.description.fil Fil: Blendy, Julie A.. The Pennsylvania State University; Estados Unidos
dc.journal.title Nicotine And Tobacco Research
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/ntr/ntv047
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ntr/article/17/12/1428/2583925
dc.conicet.fuente individual


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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)