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dc.contributor.author
Lee, Bridgin G.
dc.contributor.author
Anastasia Gonzalez, Agustin
dc.contributor.author
Hempstead, Barbara L.
dc.contributor.author
Lee, Francis S.
dc.contributor.author
Blendy, Julie A.
dc.date.available
2019-02-21T19:03:26Z
dc.date.issued
2015-12
dc.identifier.citation
Lee, Bridgin G.; Anastasia Gonzalez, Agustin; Hempstead, Barbara L.; Lee, Francis S.; Blendy, Julie A.; Effects of the BDNF Val66Met polymorphism on anxiety-like behavior following nicotine withdrawal in mice; Oxford University Press; Nicotine And Tobacco Research; 17; 12; 12-2015; 1428-1435
dc.identifier.issn
1462-2203
dc.identifier.uri
http://hdl.handle.net/11336/70638
dc.description.abstract
Introduction: Nicotine withdrawal is characterized by both affective and cognitive symptoms. Identifying genetic polymorphisms that could affect the symptoms associated with nicotine withdrawal are important in predicting withdrawal sensitivity and identifying personalized cessation therapies. In the current study we used a mouse model of a non-synonymous single nucleotide polymorphism in the translated region of the brain-derived neurotrophic factor (BDNF) gene that substitutes a valine (Val) for a methionine (Met) amino acid (Val66Met) to examine the relationship between the Val66Met single nucleotide polymorphism and nicotine dependence. Methods: This study measured proBDNF and the BDNF prodomain levels following nicotine and nicotine withdrawal and examined a mouse model of a common polymorphism in this protein (BDNFMet/Met) in three behavioral paradigms: Novelty-induced hypophagia, marble burying, and the open-field test. Results: Using the BDNF knock-in mouse containing the BDNF Val66Met polymorphism we found: (1) blunted anxiety-like behavior in BDNFMet/Met mice following withdrawal in three behavioral paradigms: Novelty-induced hypophagia, marble burying, and the open-field test; (2) the anxiolytic effects of chronic nicotine are absent in BDNFMet/Met mice; and (3) an increase in BDNF prodomain in BDNFMet/Met mice following nicotine withdrawal. Conclusions: Our study is the first to examine the effect of the BDNF Val66Met polymorphism on the affective symptoms of withdrawal from nicotine in mice. In these mice, a single-nucleotide polymorphism in the translated region of the BDNF gene can result in a blunted withdrawal, as measured by decreased anxiety-like behavior. The significant increase in the BDNF prodomain in BDNFMet/Met mice following nicotine cessation suggests a possible role of this ligand in the circuitry remodeling after withdrawal.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Bdnf
dc.subject
Val66met
dc.subject
Nicotine
dc.subject
Anxiety
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Effects of the BDNF Val66Met polymorphism on anxiety-like behavior following nicotine withdrawal in mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-02-21T14:54:05Z
dc.journal.volume
17
dc.journal.number
12
dc.journal.pagination
1428-1435
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.conicet.avisoEditorial
This is a pre-copyedited, author-produced version of an article accepted for publication in Nicotine & Tobacco Research following peer review. The version of record Lee, Bridgin G.; Anastasia Gonzalez, Agustin; Hempstead, Barbara L.; Lee, Francis S.; Blendy, Julie A.; Effects of the BDNF Val66Met polymorphism on anxiety-like behavior following nicotine withdrawal in mice; Oxford University Press; Nicotine And Tobacco Research; 17; 12; 12-2015; 1428-1435 is available online at: https://doi.org/10.1093/ntr/ntv047
dc.description.fil
Fil: Lee, Bridgin G.. The Pennsylvania State University; Estados Unidos
dc.description.fil
Fil: Anastasia Gonzalez, Agustin. Cornell University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Hempstead, Barbara L.. Cornell University; Estados Unidos
dc.description.fil
Fil: Lee, Francis S.. Cornell University; Estados Unidos
dc.description.fil
Fil: Blendy, Julie A.. The Pennsylvania State University; Estados Unidos
dc.journal.title
Nicotine And Tobacco Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/ntr/ntv047
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ntr/article/17/12/1428/2583925


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