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Artículo

Separation, Purification, and Characterization of Analogues Components of a Commercial Sample of New Fuchsin

Montes de Oca, María NoelIcon ; Aiassa Martínez, Ivana MaríaIcon ; Urrutia, María NoelIcon ; Arguello, GerardoIcon ; Ortiz, Cristina Susana
Fecha de publicación: 09/2010
Editorial: Oxford University Press
Revista: Journal Of Chromatographic Science
ISSN: 0021-9665
e-ISSN: 1945-239X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
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Resumen

New Fuchsin (NF), also known as Magenta III, has potential applications in photodynamic therapy. The commercial product labeled NF contains two other dye components in different proportions, Magenta II and Magenta I (Rosaniline). The proportions of NF, Magenta II, and Magenta I determined by reversed-phase high-performance liquid chromatography (RP-HPLC) in the commercial sample used were 71.6 +/- 0.4%, 25.2 +/- 0.2%, and 2.8 +/- 0.1% (n = 7), respectively. The isolation, purification, and characterization of commercial NF dye components were carried out applying different techniques, such as preparative column liquid chromatography (PCLC), thin layer chromatography (TLC), RP-HPLC, absorption spectrophotometry, nuclear magnetic resonance spectroscopy (NMR), electrospray ionization mass spectrometry (ESI-MS), and tandem electrospray ionization mass spectrometry (ESI-MS-MS). After separation and isolation, the degree of purity obtained for NF compound was higher than 95% and 92% for Magenta II and Magenta I compounds, respectively. Therefore, it is essential to ensure a high degree of purity of these dyes as raw material to obtain new drugs intended for therapeutic treatments.
Palabras clave: Sensibilizadores , New Fuchsin
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/70464
URL: https://academic.oup.com/chromsci/article/48/8/618/404391
DOI: http://dx.doi.org/10.1093/chromsci/48.8.618
Colecciones
Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Citación
Montes de Oca, María Noel; Aiassa Martínez, Ivana María; Urrutia, María Noel; Arguello, Gerardo; Ortiz, Cristina Susana; Separation, Purification, and Characterization of Analogues Components of a Commercial Sample of New Fuchsin; Oxford University Press; Journal Of Chromatographic Science; 48; 8; 9-2010; 618-623
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