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dc.contributor.author
Keller, Luiz
dc.contributor.author
Abrunhosa, Luís
dc.contributor.author
Keller, Kelly
dc.contributor.author
Rosa, Carlos Alberto
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Cavaglieri, Lilia Reneé
dc.contributor.author
Venâncio, Armando
dc.date.available
2019-02-18T20:44:03Z
dc.date.issued
2015-08
dc.identifier.citation
Keller, Luiz; Abrunhosa, Luís; Keller, Kelly; Rosa, Carlos Alberto; Cavaglieri, Lilia Reneé; et al.; Zearalenone and its derivatives α-zearalenol and β-zearalenol decontamination by Saccharomyces cerevisiae strains isolated from bovine forage; MDPI; Toxins; 7; 8; 8-2015; 3297-3308
dc.identifier.issn
2072-6651
dc.identifier.uri
http://hdl.handle.net/11336/70403
dc.description.abstract
Zearalenone (ZEA) and its derivatives are mycotoxins with estrogenic effects on mammals. The biotransformation for ZEA in animals involves the formation of two major metabolites, α- and β-zearalenol (α-ZOL and β-ZOL), which are subsequently conjugated with glucuronic acid. The capability of Saccharomyces cerevisiae strains isolated from silage to eliminate ZEA and its derivatives α-ZOL and β-ZOL was investigated as, also, the mechanisms involved. Strains were grown on Yeast Extract-Peptone-Dextrose medium supplemented with the mycotoxins and their elimination from medium was quantified over time by HPLC-FL. A significant effect on the concentration of ZEA was observed, as all the tested strains were able to eliminate more than 90% of the mycotoxin from the culture medium in two days. The observed elimination was mainly due to ZEA biotransformation into β-ZOL (53%) and α-ZOL (8%) rather than to its adsorption to yeast cells walls. Further, the biotransformation of α-ZOL was not observed but a small amount of β-ZOL (6%) disappeared from culture medium. ZEA biotransformation by yeasts may not be regarded as a full detoxification process because both main end-products are still estrogenic. Nonetheless, it was observed that the biotransformation favors the formation of β-ZOL which is less estrogenic than ZEA and α-ZOL. This metabolic effect is only possible if active strains are used as feed additives and may play a role in the detoxification performance of products with viable S. cerevisiae cells.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Adsorption
dc.subject
Detoxification
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Saccharomyces Cerevisiae
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Zea
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Α-Zol
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Β-Zol
dc.subject.classification
Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Zearalenone and its derivatives α-zearalenol and β-zearalenol decontamination by Saccharomyces cerevisiae strains isolated from bovine forage
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-02-15T14:31:20Z
dc.journal.volume
7
dc.journal.number
8
dc.journal.pagination
3297-3308
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Keller, Luiz. Universidade Federal Fluminense; Brasil
dc.description.fil
Fil: Abrunhosa, Luís. Universidade do Minho; Portugal
dc.description.fil
Fil: Keller, Kelly. Universidade Federal de Minas Gerais; Brasil
dc.description.fil
Fil: Rosa, Carlos Alberto. Universidade Federal Rural do Rio de Janeiro; Brasil
dc.description.fil
Fil: Cavaglieri, Lilia Reneé. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Venâncio, Armando. Universidade do Minho; Portugal
dc.journal.title
Toxins
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/toxins7083297
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6651/7/8/3297
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