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dc.contributor.author
Echazú, Adriana
dc.contributor.author
Juarez, Marisa
dc.contributor.author
Vargas Flores, Paola Andrea
dc.contributor.author
Cajal, Silvana P.
dc.contributor.author
Cimino, Rubén Oscar
dc.contributor.author
Heredia, Viviana
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Caropresi, Silvia
dc.contributor.author
Paredes, Gladys
dc.contributor.author
Arias, Luis M.
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Abril, Marcelo
dc.contributor.author
Gold, Silvia
dc.contributor.author
Lammie, Patrick
dc.contributor.author
Krolewiecki, Alejandro Javier
dc.date.available
2019-02-18T20:43:48Z
dc.date.issued
2017-10
dc.identifier.citation
Echazú, Adriana; Juarez, Marisa; Vargas Flores, Paola Andrea; Cajal, Silvana P.; Cimino, Rubén Oscar; et al.; Albendazole and ivermectin for the control of soil-transmitted helminths in an area with high prevalence of Strongyloides stercoralis and hookworm in northwestern Argentina: A community-based pragmatic study; Public Library of Science; PLoS Neglected Tropical Diseases; 11; 10; 10-2017; 1-20; e0006003
dc.identifier.issn
1935-2735
dc.identifier.uri
http://hdl.handle.net/11336/70402
dc.description.abstract
Background: Recommendations for soil-transmitted helminth (STH) control give a key role to deworming of school and pre-school age children with albendazole or mebendazole; which might be insufficient to achieve adequate control, particularly against Strongyloides stercoralis. The impact of preventive chemotherapy (PC) against STH morbidity is still incompletely understood. The aim of this study was to assess the effectiveness of a community-based program with albendazole and ivermectin in a high transmission setting for S. stercoralis and hookworm. Methodology: Community-based pragmatic trial conducted in Tartagal, Argentina; from 2012 to 2015. Six communities (5070 people) were enrolled for community-based PC with albendazole and ivermectin. Two communities (2721 people) were re-treated for second and third rounds. STH prevalence, anemia and malnutrition were explored through consecutive surveys. Anthropometric assessment of children, stool analysis, complete blood count and NIE-ELISA serology for S. stercoralis were performed. Principal findings: STH infection was associated with anemia and stunting in the baseline survey that included all communities and showed a STH prevalence of 47.6% (almost exclusively hookworm and S. stercoralis). Among communities with multiple interventions, STH prevalence decreased from 62% to 23% (p<0.001) after the first PC; anemia also diminished from 52% to 12% (p<0.001). After two interventions S. stercoralis seroprevalence declined, from 51% to 14% (p<0.001) and stunting prevalence decreased, from 19% to 12% (p = 0.009). Conclusions: Hookworm’ infections are associated with anemia in the general population and nutritional impairment in children. S. stercoralis is also associated with anemia. Community-based deworming with albendazole and ivermectin is effective for the reduction of STH prevalence and morbidity in communities with high prevalence of hookworm and S. stercoralis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Geohelminths
dc.subject
Drugs
dc.subject
Control
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Argentina
dc.subject.classification
Otras Ciencias de la Salud
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Albendazole and ivermectin for the control of soil-transmitted helminths in an area with high prevalence of Strongyloides stercoralis and hookworm in northwestern Argentina: A community-based pragmatic study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-02T19:23:09Z
dc.journal.volume
11
dc.journal.number
10
dc.journal.pagination
1-20; e0006003
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Echazú, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Salta; Argentina
dc.description.fil
Fil: Juarez, Marisa. Universidad Nacional de Salta; Argentina
dc.description.fil
Fil: Vargas Flores, Paola Andrea. Universidad Nacional de Salta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Cajal, Silvana P.. Universidad Nacional de Salta; Argentina
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Fil: Cimino, Rubén Oscar. Universidad Nacional de Salta; Argentina
dc.description.fil
Fil: Heredia, Viviana. Hospital Juan Domingo Perón; Argentina
dc.description.fil
Fil: Caropresi, Silvia. Hospital Juan Domingo Perón; Argentina
dc.description.fil
Fil: Paredes, Gladys. Hospital Juan Domingo Perón; Argentina
dc.description.fil
Fil: Arias, Luis M.. Ministerio de Salud Pública de la Provincia de Salta; Argentina
dc.description.fil
Fil: Abril, Marcelo. Fundación Mundo Sano; Argentina
dc.description.fil
Fil: Gold, Silvia. Fundación Mundo Sano; Argentina
dc.description.fil
Fil: Lammie, Patrick. Centers for Disease Control and Prevention; Estados Unidos
dc.description.fil
Fil: Krolewiecki, Alejandro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Salta; Argentina
dc.journal.title
PLoS Neglected Tropical Diseases
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1371/journal.pntd.0006003
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006003


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