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dc.contributor.author
Unsain, Nicolas
dc.contributor.author
Barker, Philip A.
dc.date.available
2019-02-12T22:32:50Z
dc.date.issued
2015-11
dc.identifier.citation
Unsain, Nicolas; Barker, Philip A.; New Views on the Misconstrued: Executioner Caspases and Their Diverse Non-apoptotic Roles; Cell Press; Neuron; 88; 3; 11-2015; 461-474
dc.identifier.issn
0896-6273
dc.identifier.uri
http://hdl.handle.net/11336/70035
dc.description.abstract
Initially characterized for their roles in apoptosis, executioner caspases have emerged as important regulators of an array of cellular activities. This is especially true in the nervous system, where sublethal caspase activity has been implicated in axonal pathfinding and branching, axonal degeneration, dendrite pruning, regeneration, long-term depression, and metaplasticity. Here we examine the roles of sublethal executioner caspase activity in nervous system development and maintenance, consider the mechanisms that locally activate and restrain these potential killers, and discuss how their activity be subverted in neurodegenerative disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Caspases
dc.subject
Nervous System
dc.subject
Xiap
dc.subject
Apoptosis
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
New Views on the Misconstrued: Executioner Caspases and Their Diverse Non-apoptotic Roles
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-02-12T18:13:49Z
dc.journal.volume
88
dc.journal.number
3
dc.journal.pagination
461-474
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Unsain, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Barker, Philip A.. University of British Columbia; Canadá
dc.journal.title
Neuron
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.neuron.2015.08.029
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0896627315007230
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