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dc.contributor.author
Alvarez, Silvina Monica
dc.contributor.author
Biaggio, Veronica Silvina
dc.contributor.author
Ciminari, Maria E.
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Piguillem, Silvana N.
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Pacheco Guiñazú, Anahi Belén
dc.contributor.author
Escobar Correas, Sophia Melanie
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Perez Chaca, Maria Valeria
dc.contributor.author
Gomez, Nidia N.
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Alvarez Olmedo, Daiana Gisela
dc.contributor.author
Fanelli, Mariel Andrea
dc.date.available
2016-08-08T15:42:43Z
dc.date.issued
2015-01
dc.identifier.citation
Alvarez, Silvina Monica; Biaggio, Veronica Silvina; Ciminari, Maria E.; Piguillem, Silvana N.; Pacheco Guiñazú, Anahi Belén; et al.; Androgen Deprivation and Cytoprotective Parameters in Rat Lung; ARC Journals; International Journal of Research Studies in Biosciences; 3; 1; 1-2015; 150-163
dc.identifier.issn
2349-0357
dc.identifier.uri
http://hdl.handle.net/11336/6987
dc.description.abstract
The aim was to study the effect of androgen deprivation, focusing on oxidative stress, and cytoprotective markers, in order to better understand the possible causes of pulmonary diseases in elder people. Adult male Wistar rats were divided into three groups: control (Co), a group subjected to castration by simple orchidectomy (Ca) and a group subjected to orchidectomy that received testosterone (100 μg/kg body weight) daily from day 25 to day 30 after castration (Ca + T). Bronchoalveolar lavages (BAL) and lungs were obtained. We observed a decrease in body weight in the castrated groups. Protein content in BAL was increased in both castrated groups while nitrites did not show differences among the groups. TBARS, Catalase (CAT) and Glutathione Peroxidase (GPx) activities were significantly increased in the castrated group, returning to the control values after the administration of testosterone. AR expression was increased in the castrated groups. Nrf-2 factor was increased in both castrated groups, while NADPH oxidase (NOX) and GPx expression increased in the Ca group but showed a decrease to control values in the Ca+T group. Superoxide Dismutase (SOD) did not show differences among the treatments. The immunohistochemistry showed a decreased expression of Hsp27 and increased expression of Hsp70 The absence of androgens induces oxidative stress in lung, together with changes in the expression of cytoprotective markers. This would lead to weak lung stroma, susceptible to undergo several pulmonary diseases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
ARC Journals
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cytoprotective Mechanisms
dc.subject
Castration
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Lung
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Patología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Androgen Deprivation and Cytoprotective Parameters in Rat Lung
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-08-04T18:18:22Z
dc.journal.volume
3
dc.journal.number
1
dc.journal.pagination
150-163
dc.journal.pais
India
dc.description.fil
Fil: Alvarez, Silvina Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
dc.description.fil
Fil: Biaggio, Veronica Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
dc.description.fil
Fil: Ciminari, Maria E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
dc.description.fil
Fil: Piguillem, Silvana N.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
dc.description.fil
Fil: Pacheco Guiñazú, Anahi Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
dc.description.fil
Fil: Escobar Correas, Sophia Melanie. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
dc.description.fil
Fil: Perez Chaca, Maria Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
dc.description.fil
Fil: Gomez, Nidia N.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
dc.description.fil
Fil: Alvarez Olmedo, Daiana Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
International Journal of Research Studies in Biosciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.arcjournals.org/pdfs/ijrsb/v3-i1/18.pdf
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