Mostrar el registro sencillo del ítem
dc.contributor.author
Verlinden, Lieve
dc.contributor.author
Verstuyf, Annemieke
dc.contributor.author
Eelen, Guy
dc.contributor.author
Bouillon, Roger
dc.contributor.author
Ordóñez-Morán, Paloma
dc.contributor.author
Larriba, María Jesús
dc.contributor.author
Muñoz, Alberto
dc.contributor.author
Rochel, Natacha
dc.contributor.author
Sato, Yoshiteru
dc.contributor.author
Moras, Dino
dc.contributor.author
Maestro, Miguel
dc.contributor.author
Seoane, Samuel
dc.contributor.author
Dominguez, Fernando
dc.contributor.author
Eduardo, Silvina Laura
dc.contributor.author
Nicoletti, Daniel
dc.contributor.author
Moman, Edelmiro
dc.contributor.author
Mouriño, Antonio
dc.date.available
2019-02-06T17:32:11Z
dc.date.issued
2011-05
dc.identifier.citation
Verlinden, Lieve; Verstuyf, Annemieke; Eelen, Guy; Bouillon, Roger; Ordóñez-Morán, Paloma; et al.; Synthesis, structure, and biological activity of des-side Chain analogues of 1α,25-Dihydroxyvitamin D3 with substituents at C18; Wiley VCH Verlag; Chemmedchem; 6; 5; 5-2011; 788-793
dc.identifier.issn
1860-7179
dc.identifier.uri
http://hdl.handle.net/11336/69536
dc.description.abstract
An improved synthetic route to 1α,25-dihydroxyvitamin D3 des-side chain analogues 2a and 2b with substituents at C18 is reported, along with their biological activity. These analogues display significant antiproliferative effects toward MCF-7 breast cancer cells and prodifferentiation activity toward SW480-ADH colon cancer cells; they are also characterized by a greatly decreased calcemic profile. The crystal structure of the human vitaminD receptor (hVDR) complexed to one of these analogues, 20(17→18)-abeo-1α,25-dihydroxy-22-homo-21-norvitamin D3 (2a) reveals that the side chain introduced at position C18 adopts the same orientation in the ligand binding pocket as the side chain of 1α,25-dihydroxyvitamin D3. Vitamin D3 supplements: The synthesis and biological activity of des-side chain analogues of 1α,25-dihydroxyvitamin D3 with substituents at C18 are described. Crystallographic analysis revealed that the new side chain introduced at C18 adopts the same orientation as the natural side chain at C17 in the parent molecule 1α,25-dihydroxyvitamin D3. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley VCH Verlag
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Biological Activity
dc.subject
Cancer
dc.subject
Steroids
dc.subject
Vitamind Analogues
dc.subject
Vitamins
dc.subject.classification
Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Synthesis, structure, and biological activity of des-side Chain analogues of 1α,25-Dihydroxyvitamin D3 with substituents at C18
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-09T14:23:01Z
dc.journal.volume
6
dc.journal.number
5
dc.journal.pagination
788-793
dc.journal.pais
Alemania
dc.journal.ciudad
Weinheim
dc.description.fil
Fil: Verlinden, Lieve. Katholikie Universiteit Leuven; Bélgica
dc.description.fil
Fil: Verstuyf, Annemieke. Katholikie Universiteit Leuven; Bélgica
dc.description.fil
Fil: Eelen, Guy. Katholikie Universiteit Leuven; Bélgica
dc.description.fil
Fil: Bouillon, Roger. Katholikie Universiteit Leuven; Bélgica
dc.description.fil
Fil: Ordóñez-Morán, Paloma. Universidad Autónoma de Madrid; España
dc.description.fil
Fil: Larriba, María Jesús. Universidad Autónoma de Madrid; España
dc.description.fil
Fil: Muñoz, Alberto. Universidad Autónoma de Madrid; España
dc.description.fil
Fil: Rochel, Natacha. Université de Strasbourg; Francia
dc.description.fil
Fil: Sato, Yoshiteru. Université de Strasbourg; Francia
dc.description.fil
Fil: Moras, Dino. Université de Strasbourg; Francia
dc.description.fil
Fil: Maestro, Miguel. Universidad da Coruña; España
dc.description.fil
Fil: Seoane, Samuel. Universidad de Santiago de Compostela, Facultad de Medicina;
dc.description.fil
Fil: Dominguez, Fernando. Universidad de Santiago de Compostela, Facultad de Medicina;
dc.description.fil
Fil: Eduardo, Silvina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Nicoletti, Daniel. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Moman, Edelmiro. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Mouriño, Antonio. Universidad de Santiago de Compostela; España
dc.journal.title
Chemmedchem
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1002/cmdc.201100021
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201100021
Archivos asociados