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Artículo

Molecular Mechanisms of Glucocorticoids Action: From Basic Research to Clinical Implications

Liberman, Ana ClaraIcon ; Castro, Carla NoemíIcon ; Antunica Noguerol, María de Las NievesIcon ; Barcala Tabarrozzi, Andrés EzequielIcon ; Druker, Jimena PaolaIcon ; Perone, Marcelo JavierIcon ; Arzt, Eduardo SimonIcon
Fecha de publicación: 11/2010
Editorial: Bentham Science Publishers
Revista: Current Immunology Reviews
ISSN: 1573-3955
e-ISSN: 1875-631X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Naturales y Exactas

Resumen

Glucocorticoid hormones (GCs) have pleiotropic activities in the body playing important roles in metabolism and modulating/regulating the stress and immune responses. Upon stimuli that trigger immune or inflammatory responses there is a concomitant activation of the hypothalamus-pituitary-adrenal axis ultimately manifested by an increase in the synthesis and release of GCs to the systemic circulation. GCs play a pivotal role in the interface between the<br />neuroendocrine and immune systems by modulating the final outcome of the immune response. The successful resolution of an immune response depends on the fine tune interplay between GCs and cytokines. The interaction between intracellular signals elicited by cytokines and the activated glucocorticoid receptor (GR) results in the induction or repression of gene transcription coordinating an effective immune response, and then its resolution avoiding excessive deleterious reactions. Herein, we described recent knowledge regarding basic research in the complex interaction between GCs and components of the immune system at cellular and molecular levels, as well as their clinical implications for health and disease. The benefits of therapeutic GCs controlling immune disorders as well as their misconduct are also discussed in terms of considering the benefits and adverse effects to control disease and inflammation.
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/69085
DOI: http://dx.doi.org/10.2174/1573395511006040371
URL: http://dx.doi.org/ www.eurekaselect.com/86961/article
Colecciones
Articulos(IBIOBA - MPSP)
Articulos de INST. D/INV.EN BIOMED.DE BS AS-CONICET-INST. PARTNER SOCIEDAD MAX PLANCK
Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Citación
Liberman, Ana Clara; Castro, Carla Noemí; Antunica Noguerol, María de Las Nieves; Barcala Tabarrozzi, Andrés Ezequiel; Druker, Jimena Paola; et al.; Molecular Mechanisms of Glucocorticoids Action: From Basic Research to Clinical Implications; Bentham Science Publishers; Current Immunology Reviews; 6; 4; 11-2010; 371-380
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