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dc.contributor.author
Lavagnino, Nicolas Jose
dc.contributor.author
Serra, François
dc.contributor.author
Arbiza, Leonardo
dc.contributor.author
Dopazo, Hernán Javier
dc.contributor.author
Hasson, Esteban Ruben
dc.date.available
2019-01-30T19:08:19Z
dc.date.issued
2012-01
dc.identifier.citation
Lavagnino, Nicolas Jose; Serra, François; Arbiza, Leonardo; Dopazo, Hernán Javier; Hasson, Esteban Ruben; Evolutionary Genomics of Genes Involved in Olfactory Behavior in the Drosophila melanogaster Species Group; Bioinformatics Inst; Evolutionary Bioinformatics; 2011; 7; 1-2012; 89-104
dc.identifier.issn
1176-9343
dc.identifier.uri
http://hdl.handle.net/11336/69052
dc.description.abstract
Previous comparative genomic studies of genes involved in olfactory behavior in Drosophila focused only on particular gene families such as odorant receptor and/or odorant binding proteins. However, olfactory behavior has a complex genetic architecture that is orchestrated by many interacting genes. In this paper, we present a comparative genomic study of olfactory behavior in Drosophila including an extended set of genes known to affect olfactory behavior. We took advantage of the recent burst of whole genome sequences and the development of powerful statistical tools to analyze genomic data and test evolutionary and functional hypotheses of olfactory genes in the six species of the Drosophila melanogaster species group for which whole genome sequences are available. Our study reveals widespread purifying selection and limited incidence of positive selection on olfactory genes. We show that the pace of evolution of olfactory genes is mostly independent of the life cycle stage, and of the number of life cycle stages, in which they participate in olfaction. However, we detected a relationship between evolutionary rates and the position that the gene products occupy in the olfactory system, genes occupying central positions tend to be more constrained than peripheral genes. Finally, we demonstrate that specialization to one host does not seem to be associated with bursts of adaptive evolution in olfactory genes in D. sechellia and D. erecta, the two specialists species analyzed, but rather different lineages have idiosyncratic evolutionary histories in which both historical and ecological factors have been involved.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bioinformatics Inst
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
Adaptation
dc.subject
Drosophila Melanogaster Species Group
dc.subject
Evolutionary Genomics
dc.subject
Insects
dc.subject
Olfactory Behavior
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Evolutionary Genomics of Genes Involved in Olfactory Behavior in the Drosophila melanogaster Species Group
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-28T14:13:43Z
dc.journal.volume
2011
dc.journal.number
7
dc.journal.pagination
89-104
dc.journal.pais
Nueva Zelanda
dc.journal.ciudad
Albany
dc.description.fil
Fil: Lavagnino, Nicolas Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; Argentina
dc.description.fil
Fil: Serra, François. Centro de Investigaciones Príncipe Felipe; España
dc.description.fil
Fil: Arbiza, Leonardo. Centro de Investigaciones Príncipe Felipe; España
dc.description.fil
Fil: Dopazo, Hernán Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; Argentina
dc.description.fil
Fil: Hasson, Esteban Ruben. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; Argentina
dc.journal.title
Evolutionary Bioinformatics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.4137/EBO.S8484
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.4137/EBO.S8484
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273929/


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