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dc.contributor.author Lavagnino, Nicolas Jose
dc.contributor.author Serra, François
dc.contributor.author Arbiza, Leonardo
dc.contributor.author Dopazo, Hernán Javier
dc.contributor.author Hasson, Esteban Ruben
dc.date.available 2019-01-30T19:08:19Z
dc.date.issued 2012-01
dc.identifier.citation Lavagnino, Nicolas Jose; Serra, François; Arbiza, Leonardo; Dopazo, Hernán Javier; Hasson, Esteban Ruben; Evolutionary Genomics of Genes Involved in Olfactory Behavior in the Drosophila melanogaster Species Group; Bioinformatics Inst; Evolutionary Bioinformatics; 2011; 7; 1-2012; 89-104
dc.identifier.issn 1176-9343
dc.identifier.uri http://hdl.handle.net/11336/69052
dc.description.abstract Previous comparative genomic studies of genes involved in olfactory behavior in Drosophila focused only on particular gene families such as odorant receptor and/or odorant binding proteins. However, olfactory behavior has a complex genetic architecture that is orchestrated by many interacting genes. In this paper, we present a comparative genomic study of olfactory behavior in Drosophila including an extended set of genes known to affect olfactory behavior. We took advantage of the recent burst of whole genome sequences and the development of powerful statistical tools to analyze genomic data and test evolutionary and functional hypotheses of olfactory genes in the six species of the Drosophila melanogaster species group for which whole genome sequences are available. Our study reveals widespread purifying selection and limited incidence of positive selection on olfactory genes. We show that the pace of evolution of olfactory genes is mostly independent of the life cycle stage, and of the number of life cycle stages, in which they participate in olfaction. However, we detected a relationship between evolutionary rates and the position that the gene products occupy in the olfactory system, genes occupying central positions tend to be more constrained than peripheral genes. Finally, we demonstrate that specialization to one host does not seem to be associated with bursts of adaptive evolution in olfactory genes in D. sechellia and D. erecta, the two specialists species analyzed, but rather different lineages have idiosyncratic evolutionary histories in which both historical and ecological factors have been involved.
dc.format application/pdf
dc.language.iso eng
dc.publisher Bioinformatics Inst
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject ADAPTATION
dc.subject DROSOPHILA MELANOGASTER SPECIES GROUP
dc.subject EVOLUTIONARY GENOMICS
dc.subject INSECTS
dc.subject OLFACTORY BEHAVIOR
dc.subject.classification Otras Ciencias Biológicas
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Evolutionary Genomics of Genes Involved in Olfactory Behavior in the Drosophila melanogaster Species Group
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2019-01-28T14:13:43Z
dc.journal.volume 2011
dc.journal.number 7
dc.journal.pagination 89-104
dc.journal.pais Nueva Zelanda
dc.journal.ciudad Albany
dc.description.fil Fil: Lavagnino, Nicolas Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; Argentina
dc.description.fil Fil: Serra, François. Centro de Investigaciones Príncipe Felipe; España
dc.description.fil Fil: Arbiza, Leonardo. Centro de Investigaciones Príncipe Felipe; España
dc.description.fil Fil: Dopazo, Hernán Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; Argentina
dc.description.fil Fil: Hasson, Esteban Ruben. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; Argentina
dc.journal.title Evolutionary Bioinformatics
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.4137/EBO.S8484
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.4137/EBO.S8484
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273929/
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial 2.5 Unported (CC BY-NC 2.5)