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dc.contributor.author
Hernando Insúa, Andrés
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Rodriguez, Juan M.
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Elías, Fernanda
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Fló, Juan
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López, Ricardo
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Franco, Raul
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Lago, Nestor
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Zorzopulos, Jorge
dc.contributor.author
Montaner, Alejandro Daniel
dc.date.available
2019-01-29T20:22:59Z
dc.date.issued
2010-02
dc.identifier.citation
Hernando Insúa, Andrés; Rodriguez, Juan M.; Elías, Fernanda; Fló, Juan; López, Ricardo; et al.; A high dose of IMT504, the PyNTTTTGT prototype immunostimulatory oligonucleotide, does not alter embryonic development in rats; Mary Ann Liebert; Oligonucleotides; 20; 1; 2-2010; 33-35
dc.identifier.issn
1545-4576
dc.identifier.uri
http://hdl.handle.net/11336/68917
dc.description.abstract
Synthetic oligodeoxynucleotides (ODNs) are currently being evaluated as vaccine adjuvants for inducing protective immunity. As maternal vaccination is becoming increasingly common, the potential risk of vaccine formulation using ODN adjuvants should be warranted. A recent study performed in mice suggests that exposure to CpG motifs during pregnancy could result (although at very high doses as compared to the ones proposed for human vaccination) in fetal loss and morphological defects. PyNTTTTGT ODNs are immunostimulatory ODNs not bearing CpG motifs, which are very efficient vaccine adjuvants. In this report, we analyzed the potential teratogenic effect of its prototype IMT504 in rats. This animal model was chosen because PyNTTTTGT ODNs are barely active in mice. Intraperitoneal injection of IMT504 at a dose of 20 mg/kg (more than 1000 times higher than the one proposed for a vaccine dose in humans) at day 6 of pregnancy did not produce a significant decrease in the mean number of implanted fetuses or in the number of live pups delivered. Neither the fetuses nor the offspring presented malformations.
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application/pdf
dc.language.iso
eng
dc.publisher
Mary Ann Liebert
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Pynttttgt Odn
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Oligonucleotides
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Toxicity
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Otras Biotecnologías de la Salud
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Biotecnología de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
A high dose of IMT504, the PyNTTTTGT prototype immunostimulatory oligonucleotide, does not alter embryonic development in rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-29T18:07:58Z
dc.journal.volume
20
dc.journal.number
1
dc.journal.pagination
33-35
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Hernando Insúa, Andrés. Immunotech; Argentina
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Fil: Rodriguez, Juan M.. Immunotech; Argentina
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Fil: Elías, Fernanda. Immunotech; Argentina
dc.description.fil
Fil: Fló, Juan. Immunotech; Argentina
dc.description.fil
Fil: López, Ricardo. Immunotech; Argentina
dc.description.fil
Fil: Franco, Raul. Immunotech; Argentina
dc.description.fil
Fil: Lago, Nestor. Gema Biotech; Argentina
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Fil: Zorzopulos, Jorge. Immunotech; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Montaner, Alejandro Daniel. Immunotech; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; Argentina
dc.journal.title
Oligonucleotides
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1089/oli.2009.0206
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/10.1089/oli.2009.0206