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dc.contributor.author
Hernando Insúa, Andrés  
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Rodriguez, Juan M.  
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Elías, Fernanda  
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Fló, Juan  
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López, Ricardo  
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Franco, Raul  
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Lago, Nestor  
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Zorzopulos, Jorge  
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Montaner, Alejandro Daniel  
dc.date.available
2019-01-29T20:22:59Z  
dc.date.issued
2010-02  
dc.identifier.citation
Hernando Insúa, Andrés; Rodriguez, Juan M.; Elías, Fernanda; Fló, Juan; López, Ricardo; et al.; A high dose of IMT504, the PyNTTTTGT prototype immunostimulatory oligonucleotide, does not alter embryonic development in rats; Mary Ann Liebert; Oligonucleotides; 20; 1; 2-2010; 33-35  
dc.identifier.issn
1545-4576  
dc.identifier.uri
http://hdl.handle.net/11336/68917  
dc.description.abstract
Synthetic oligodeoxynucleotides (ODNs) are currently being evaluated as vaccine adjuvants for inducing protective immunity. As maternal vaccination is becoming increasingly common, the potential risk of vaccine formulation using ODN adjuvants should be warranted. A recent study performed in mice suggests that exposure to CpG motifs during pregnancy could result (although at very high doses as compared to the ones proposed for human vaccination) in fetal loss and morphological defects. PyNTTTTGT ODNs are immunostimulatory ODNs not bearing CpG motifs, which are very efficient vaccine adjuvants. In this report, we analyzed the potential teratogenic effect of its prototype IMT504 in rats. This animal model was chosen because PyNTTTTGT ODNs are barely active in mice. Intraperitoneal injection of IMT504 at a dose of 20 mg/kg (more than 1000 times higher than the one proposed for a vaccine dose in humans) at day 6 of pregnancy did not produce a significant decrease in the mean number of implanted fetuses or in the number of live pups delivered. Neither the fetuses nor the offspring presented malformations.  
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application/pdf  
dc.language.iso
eng  
dc.publisher
Mary Ann Liebert  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Pynttttgt Odn  
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Oligonucleotides  
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Toxicity  
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Otras Biotecnologías de la Salud  
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Biotecnología de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
A high dose of IMT504, the PyNTTTTGT prototype immunostimulatory oligonucleotide, does not alter embryonic development in rats  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-01-29T18:07:58Z  
dc.journal.volume
20  
dc.journal.number
1  
dc.journal.pagination
33-35  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Hernando Insúa, Andrés. Immunotech; Argentina  
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Fil: Rodriguez, Juan M.. Immunotech; Argentina  
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Fil: Elías, Fernanda. Immunotech; Argentina  
dc.description.fil
Fil: Fló, Juan. Immunotech; Argentina  
dc.description.fil
Fil: López, Ricardo. Immunotech; Argentina  
dc.description.fil
Fil: Franco, Raul. Immunotech; Argentina  
dc.description.fil
Fil: Lago, Nestor. Gema Biotech; Argentina  
dc.description.fil
Fil: Zorzopulos, Jorge. Immunotech; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Montaner, Alejandro Daniel. Immunotech; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; Argentina  
dc.journal.title
Oligonucleotides  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1089/oli.2009.0206  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/10.1089/oli.2009.0206