Mostrar el registro sencillo del ítem

dc.contributor.author
Labeur, Marta
dc.contributor.author
Páez Pereda, Marcelo
dc.contributor.author
Haedo, Mariana Raquel
dc.contributor.author
Arzt, Eduardo Simon
dc.contributor.author
Stalla, Günter K.
dc.date.available
2019-01-29T20:22:38Z
dc.date.issued
2010-09
dc.identifier.citation
Labeur, Marta; Páez Pereda, Marcelo; Haedo, Mariana Raquel; Arzt, Eduardo Simon; Stalla, Günter K.; Pituitary tumors: Cell type-specific roles for BMP-4; Elsevier Ireland; Molecular and Cellular Endocrinology; 326; 1-2; 9-2010; 85-88
dc.identifier.issn
0303-7207
dc.identifier.uri
http://hdl.handle.net/11336/68915
dc.description.abstract
BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and lactotroph cell proliferation through a Smad-estrogen receptor crosstalk but it inhibits ACTH production and cell proliferation of corticotrophs. In addition, BMP-4 increases GH secretion in rat pituitary tumor somatolactotroph GH3 cells and FSHβ subunit gene transcription in the murine gonadotroph cell line, LβT2. Therefore, BMP-4 has a differential role on different types of pituitary tumors: it promotes pituitary prolactinoma while it inhibits corticotroph pathogenesis in Cushing's disease. The modulation of BMP-4 also plays an important role in the therapeutic mechanism of action of bromocriptine, somatostatin analogs and retinoic acid.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Acth
dc.subject
Bmp-4
dc.subject
Pituitary Tumors
dc.subject
Prolactin
dc.subject
Retinoic Acid
dc.subject
Tgf-Β
dc.subject.classification
Otras Medicina Básica
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Pituitary tumors: Cell type-specific roles for BMP-4
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-29T18:09:27Z
dc.journal.volume
326
dc.journal.number
1-2
dc.journal.pagination
85-88
dc.journal.pais
Irlanda
dc.description.fil
Fil: Labeur, Marta. Max Planck Institute of Psychiatry; Alemania
dc.description.fil
Fil: Páez Pereda, Marcelo. Max Planck Institute of Psychiatry; Alemania
dc.description.fil
Fil: Haedo, Mariana Raquel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Arzt, Eduardo Simon. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Stalla, Günter K.. Max Planck Institute of Psychiatry; Alemania
dc.journal.title
Molecular and Cellular Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.mce.2010.04.006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S030372071000211X


Archivos asociados

Documento no disponible

Comunidades y colecciones

Mostrar el registro sencillo del ítem