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dc.contributor.author
Fabersani Marrades, Mario Emanuel
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dc.contributor.author
Torres, Sebastián
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dc.contributor.author
Valdez, C.
dc.contributor.author
Gonzalez, Silvia Nelina
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dc.contributor.author
Gauffin Cano, María Paola
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dc.date.available
2016-08-02T19:44:00Z
dc.date.issued
2014-09-18
dc.identifier.citation
Fabersani Marrades, Mario Emanuel; Torres, Sebastián; Valdez, C.; Gonzalez, Silvia Nelina; Gauffin Cano, María Paola; Fermented Milks from Small Ruminant: Effect on Metabolism and Immune Status of Mice Fed Mild Caloric Restricted Diet; Austin Publishing Group; Journal of Immune Research; 1; 2; 18-9-2014; 1-10
dc.identifier.issn
2381-909X
dc.identifier.uri
http://hdl.handle.net/11336/6881
dc.description.abstract
The purpose of this study was to evaluate the effect of the administration of Fermented Goat´S Milks (FGMs) in mice fed mild caloric restricted diet. The ability of these FGMs to ameliorate immune and metabolic parameters related to mild caloric restriction was studied. We also analyzed if the time (45 or 90 days) of caloric restriction have influence on leptin secretion, IgA+ cells number and phagocytic activity of peritoneal macrophages, and also test the correlation between these parameters. Mice were fed with a mild caloric restricted diet during 45 or 90 days. After these periods of caloric restriction, mice were refed with balanced conventional diet (BCD) plus goat´s milks or BCD plus goat´s milks fermented with Lactobacillus rhamnosus CRL1425 (FGM-Lr) or Lactobacillus casei CRL431 (FGM-Lc). All renutrition diets induced an increase of serum glucose, triglycerides, total proteins and leucocytes cells. A decrease in cholesterol levels was observed after the diets. FGM-Lr induced lower triglycerides values than others diets. All FGMs restore IgA+ cells in intestinal mucosa, and the FGM-Lc group had higher positive cells number than the ad libitum control. Furthermore, phagocytic activity of peritoneal macrophages only increased in mice fed with FGM-Lc. Mild caloric restriction induced a decrease on leptin circulating values at 90 days. The renutrition with FGM-Lr lead to lower leptin levels than mild caloric restriction controls, while FGM-Lc induced higher leptin levels. Positive correlation between serum leptin concentration and immune parameters was observed in all groups under study. We showed that leptin levels could positively predict the immune mucosal competence in mild caloric restricted mice. These results suggest that the FGMs are able to modulate, in different way, serum leptin levels, IgA+ cells number and phagocytic activity. Furthermore, FGM-Lc could be more effective for nutritional treatment in malnutrition status.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Austin Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Mild Caloric Restriction
dc.subject
Leptin Renutrition
dc.subject
Goat`S Milk
dc.subject
Probiotic
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Fermented Milks from Small Ruminant: Effect on Metabolism and Immune Status of Mice Fed Mild Caloric Restricted Diet
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-07-25T19:31:49Z
dc.journal.volume
1
dc.journal.number
2
dc.journal.pagination
1-10
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Fabersani Marrades, Mario Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
dc.description.fil
Fil: Torres, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán; Argentina
dc.description.fil
Fil: Valdez, C.. Universidad Nacional de Tucumán; Argentina
dc.description.fil
Fil: Gonzalez, Silvia Nelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina. Universidad Nacional de Tucumán; Argentina
dc.description.fil
Fil: Gauffin Cano, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina. Universidad del Norte Santo Tomás de Aquino; Argentina
dc.journal.title
Journal of Immune Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://austinpublishinggroup.com/immune-research/download.php?file=fulltext/immunes-v1-id1007.pdf
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