Artículo
Trans-sialidase and mucins of Trypanosoma cruzi: An important interplay for the parasite
Fecha de publicación:
09/2011
Editorial:
Elsevier
Revista:
Carbohydrate Research
ISSN:
0008-6215
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A dense glycocalix covers the surface of Trypanosoma cruzi, the agent of Chagas disease. Sialic acid in the surface of the parasite plays an important role in the infectious process, however, T. cruzi is unable to synthesize sialic acid or the usual donor CMP-sialic acid. Instead, T. cruzi expresses a unique enzyme, the trans-sialidase (TcTS) involved in the transfer of sialic acid from host glycoconjugates to mucins of the parasite. The mucins are the major glycoproteins in the insect stage epimastigotes and in the infective trypomastigotes. Both, the mucins and the TcTS are anchored to the plasma membrane by a glycosylphosphatidylinositol anchor. Thus, TcTS may be shed into the bloodstream of the mammal host by the action of a parasite phosphatidylinositol-phospholipase C, affecting the immune system. The composition and structure of the sugars in the parasite mucins is characteristic of each differentiation stage, also, interstrain variations were described for epimastigote mucins. This review focus on the characteristics of the interplay between the trans-sialidase and the mucins of T. cruzi and summarizes the known carbohydrate structures of the mucins.
Palabras clave:
Chagas Disease
,
Mucins
,
Trans-Sialidase
,
Trypanosoma Cruzi
Archivos asociados
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Identificadores
Colecciones
Articulos(CIHIDECAR)
Articulos de CENTRO DE INVESTIGACIONES EN HIDRATOS DE CARBONO
Articulos de CENTRO DE INVESTIGACIONES EN HIDRATOS DE CARBONO
Citación
Giorgi, María Eugenia; Muchnik, Rosa; Trans-sialidase and mucins of Trypanosoma cruzi: An important interplay for the parasite; Elsevier; Carbohydrate Research; 346; 12; 9-2011; 1389-1393
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