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dc.contributor.author
Morán, Ignasi
dc.contributor.author
Akerman, Ildem
dc.contributor.author
Van De Bunt, Martijn
dc.contributor.author
Xie, Ruiyu
dc.contributor.author
Benazra, Marion
dc.contributor.author
Nammo, Takao
dc.contributor.author
Arnes, Luis
dc.contributor.author
Nakic, Nikolina
dc.contributor.author
García Hurtado, Javier
dc.contributor.author
Rodríguez Seguí, Santiago Andrés
dc.contributor.author
Pasquali, Lorenzo
dc.contributor.author
Sauty Colace, Claire
dc.contributor.author
Beucher, Anthony
dc.contributor.author
Scharfmann, Raphael
dc.contributor.author
Van Arensbergen, Joris
dc.contributor.author
Johnson, Paul R.
dc.contributor.author
Berry, Andrew
dc.contributor.author
Lee, Clarence
dc.contributor.author
Harkins, Timothy
dc.contributor.author
Gmyr, Valery
dc.contributor.author
Pattou, François
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Kerr Conte, Julie
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Piemonti, Lorenzo
dc.contributor.author
Berney, Thierry
dc.contributor.author
Hanley, Neil
dc.contributor.author
Gloyn, Anna L.
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Sussel, Lori
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Langman, Linda
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Brayman, Kenneth L.
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Sander, Maike
dc.contributor.author
McCarthy, Mark I.
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Ravassard, Philippe
dc.contributor.author
Ferrer, Jorge
dc.date.available
2019-01-24T15:00:20Z
dc.date.issued
2012-10
dc.identifier.citation
Morán, Ignasi; Akerman, Ildem; Van De Bunt, Martijn; Xie, Ruiyu; Benazra, Marion; et al.; Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes; Cell Press; Cell Metabolism; 16; 4; 10-2012; 435-448
dc.identifier.issn
1550-4131
dc.identifier.uri
http://hdl.handle.net/11336/68501
dc.description.abstract
A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several of which are known to control gene expression. The repertoire and regulation of lncRNAs in disease-relevant tissues, however, has not been systematically explored. We report a comprehensive strand-specific transcriptome map of human pancreatic islets and β cells, and uncover >1100 intergenic and antisense islet-cell lncRNA genes. We find islet lncRNAs that are dynamically regulated and show that they are an integral component of the β cell differentiation and maturation program. We sequenced the mouse islet transcriptome and identify lncRNA orthologs that are regulated like their human counterparts. Depletion of HI-LNC25, a β cell-specific lncRNA, downregulated GLIS3 mRNA, thus exemplifying a gene regulatory function of islet lncRNAs. Finally, selected islet lncRNAs were dysregulated in type 2 diabetes or mapped to genetic loci underlying diabetes susceptibility. These findings reveal a new class of islet-cell genes relevant to β cell programming and diabetes pathophysiology.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Beta Cell
dc.subject
Pancreas
dc.subject
Noncoding Rna
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Diabetes
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Fisiología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Otras Ciencias Biológicas
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-16T18:17:44Z
dc.journal.volume
16
dc.journal.number
4
dc.journal.pagination
435-448
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Morán, Ignasi. Institut d’Investigacions Biomediques August Pi I Sunyer; España
dc.description.fil
Fil: Akerman, Ildem. Institut d’Investigacions Biomediques August Pi I Sunyer; España
dc.description.fil
Fil: Van De Bunt, Martijn. University of Oxford; Reino Unido. Churchill Hospital; Reino Unido
dc.description.fil
Fil: Xie, Ruiyu. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: Benazra, Marion. Universite Pierre et Marie Curie; Francia
dc.description.fil
Fil: Nammo, Takao. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España. National Center for Global Health and Medicine; Japón
dc.description.fil
Fil: Arnes, Luis. Columbia University; Estados Unidos
dc.description.fil
Fil: Nakic, Nikolina. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España
dc.description.fil
Fil: García Hurtado, Javier. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España
dc.description.fil
Fil: Rodríguez Seguí, Santiago Andrés. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Pasquali, Lorenzo. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España
dc.description.fil
Fil: Sauty Colace, Claire. Universite Pierre et Marie Curie; Francia
dc.description.fil
Fil: Beucher, Anthony. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España
dc.description.fil
Fil: Scharfmann, Raphael. Inserm; Francia
dc.description.fil
Fil: Van Arensbergen, Joris. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España
dc.description.fil
Fil: Johnson, Paul R.. Churchill Hospital; Reino Unido. John Radcliffe Hospital; Reino Unido
dc.description.fil
Fil: Berry, Andrew. University of Manchester; Reino Unido
dc.description.fil
Fil: Lee, Clarence. Life Technologies; Estados Unidos
dc.description.fil
Fil: Harkins, Timothy. Life Technologies; Estados Unidos
dc.description.fil
Fil: Gmyr, Valery. University of Lille Nord; Francia
dc.description.fil
Fil: Pattou, François. University of Lille Nord; Francia
dc.description.fil
Fil: Kerr Conte, Julie. University of Lille Nord; Francia
dc.description.fil
Fil: Piemonti, Lorenzo. San Raffaele Scientific Institute; Italia
dc.description.fil
Fil: Berney, Thierry. Cell Isolation and Transplantation Center; Suiza
dc.description.fil
Fil: Hanley, Neil. University of Manchester; Reino Unido
dc.description.fil
Fil: Gloyn, Anna L.. Churchill Hospital; Reino Unido
dc.description.fil
Fil: Sussel, Lori. Columbia University; Estados Unidos
dc.description.fil
Fil: Langman, Linda. University of Virginia; Estados Unidos
dc.description.fil
Fil: Brayman, Kenneth L.. University of Virginia; Estados Unidos
dc.description.fil
Fil: Sander, Maike. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: McCarthy, Mark I.. Churchill Hospital; Reino Unido. University of Oxford; Reino Unido. San Raffaele Scientific Institute; Italia
dc.description.fil
Fil: Ravassard, Philippe. Universite Pierre et Marie Curie; Francia
dc.description.fil
Fil: Ferrer, Jorge. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España. Hospital Clinic de Barcelona; España
dc.journal.title
Cell Metabolism
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cmet.2012.08.010
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1550413112003610


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