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dc.contributor.author
Morán, Ignasi  
dc.contributor.author
Akerman, Ildem  
dc.contributor.author
Van De Bunt, Martijn  
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Xie, Ruiyu  
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Benazra, Marion  
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Nammo, Takao  
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Arnes, Luis  
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Nakic, Nikolina  
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García Hurtado, Javier  
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Rodríguez Seguí, Santiago Andrés  
dc.contributor.author
Pasquali, Lorenzo  
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Sauty Colace, Claire  
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Beucher, Anthony  
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Scharfmann, Raphael  
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Van Arensbergen, Joris  
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Johnson, Paul R.  
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Berry, Andrew  
dc.contributor.author
Lee, Clarence  
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Harkins, Timothy  
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Gmyr, Valery  
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Pattou, François  
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Kerr Conte, Julie  
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Piemonti, Lorenzo  
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Berney, Thierry  
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Hanley, Neil  
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Gloyn, Anna L.  
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Sussel, Lori  
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Langman, Linda  
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Brayman, Kenneth L.  
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Sander, Maike  
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McCarthy, Mark I.  
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Ravassard, Philippe  
dc.contributor.author
Ferrer, Jorge  
dc.date.available
2019-01-24T15:00:20Z  
dc.date.issued
2012-10  
dc.identifier.citation
Morán, Ignasi; Akerman, Ildem; Van De Bunt, Martijn; Xie, Ruiyu; Benazra, Marion; et al.; Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes; Cell Press; Cell Metabolism; 16; 4; 10-2012; 435-448  
dc.identifier.issn
1550-4131  
dc.identifier.uri
http://hdl.handle.net/11336/68501  
dc.description.abstract
A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several of which are known to control gene expression. The repertoire and regulation of lncRNAs in disease-relevant tissues, however, has not been systematically explored. We report a comprehensive strand-specific transcriptome map of human pancreatic islets and β cells, and uncover >1100 intergenic and antisense islet-cell lncRNA genes. We find islet lncRNAs that are dynamically regulated and show that they are an integral component of the β cell differentiation and maturation program. We sequenced the mouse islet transcriptome and identify lncRNA orthologs that are regulated like their human counterparts. Depletion of HI-LNC25, a β cell-specific lncRNA, downregulated GLIS3 mRNA, thus exemplifying a gene regulatory function of islet lncRNAs. Finally, selected islet lncRNAs were dysregulated in type 2 diabetes or mapped to genetic loci underlying diabetes susceptibility. These findings reveal a new class of islet-cell genes relevant to β cell programming and diabetes pathophysiology.  
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application/pdf  
dc.language.iso
eng  
dc.publisher
Cell Press  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
Beta Cell  
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Pancreas  
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Noncoding Rna  
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Diabetes  
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Fisiología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
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Otras Ciencias Biológicas  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-01-16T18:17:44Z  
dc.journal.volume
16  
dc.journal.number
4  
dc.journal.pagination
435-448  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Morán, Ignasi. Institut d’Investigacions Biomediques August Pi I Sunyer; España  
dc.description.fil
Fil: Akerman, Ildem. Institut d’Investigacions Biomediques August Pi I Sunyer; España  
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Fil: Van De Bunt, Martijn. University of Oxford; Reino Unido. Churchill Hospital; Reino Unido  
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Fil: Xie, Ruiyu. University of California at San Diego; Estados Unidos  
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Fil: Benazra, Marion. Universite Pierre et Marie Curie; Francia  
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Fil: Nammo, Takao. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España. National Center for Global Health and Medicine; Japón  
dc.description.fil
Fil: Arnes, Luis. Columbia University; Estados Unidos  
dc.description.fil
Fil: Nakic, Nikolina. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España  
dc.description.fil
Fil: García Hurtado, Javier. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España  
dc.description.fil
Fil: Rodríguez Seguí, Santiago Andrés. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Pasquali, Lorenzo. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España  
dc.description.fil
Fil: Sauty Colace, Claire. Universite Pierre et Marie Curie; Francia  
dc.description.fil
Fil: Beucher, Anthony. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España  
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Fil: Scharfmann, Raphael. Inserm; Francia  
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Fil: Van Arensbergen, Joris. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España  
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Fil: Johnson, Paul R.. Churchill Hospital; Reino Unido. John Radcliffe Hospital; Reino Unido  
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Fil: Berry, Andrew. University of Manchester; Reino Unido  
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Fil: Lee, Clarence. Life Technologies; Estados Unidos  
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Fil: Harkins, Timothy. Life Technologies; Estados Unidos  
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Fil: Gmyr, Valery. University of Lille Nord; Francia  
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Fil: Pattou, François. University of Lille Nord; Francia  
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Fil: Kerr Conte, Julie. University of Lille Nord; Francia  
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Fil: Piemonti, Lorenzo. San Raffaele Scientific Institute; Italia  
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Fil: Berney, Thierry. Cell Isolation and Transplantation Center; Suiza  
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Fil: Hanley, Neil. University of Manchester; Reino Unido  
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Fil: Gloyn, Anna L.. Churchill Hospital; Reino Unido  
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Fil: Sussel, Lori. Columbia University; Estados Unidos  
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Fil: Langman, Linda. University of Virginia; Estados Unidos  
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Fil: Brayman, Kenneth L.. University of Virginia; Estados Unidos  
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Fil: Sander, Maike. University of California at San Diego; Estados Unidos  
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Fil: McCarthy, Mark I.. Churchill Hospital; Reino Unido. University of Oxford; Reino Unido. San Raffaele Scientific Institute; Italia  
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Fil: Ravassard, Philippe. Universite Pierre et Marie Curie; Francia  
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Fil: Ferrer, Jorge. Institut d’Investigacions Biomediques August Pi I Sunyer; España. CIBER de Diabetes y Enfermedades Metabólicas Asociadas; España. Hospital Clinic de Barcelona; España  
dc.journal.title
Cell Metabolism  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cmet.2012.08.010  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1550413112003610