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Artículo

Spray drying formulation of albendazole microspheres by experimental design. In vitro–in vivo studies

García, AgustinaIcon ; Olivieri, Alejandro CesarIcon ; Piccirilli, Gisela NoemiIcon ; Mamprin, María EugeniaIcon ; Olivieri, Alejandro CesarIcon ; Lamas, Maria CelinaIcon
Fecha de publicación: 11/2013
Editorial: Taylor & Francis
Revista: Drug Development and Industrial Pharmacy
ISSN: 0363-9045
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Farmacología y Farmacia

Resumen

Both an experimental design and optimization techniques were carried out for the development of chitosan–pectin–carboxymethylcellulose microspheres to improve the oral absorption of albendazole as a model drug. The effect of three different factors (chitosan, pectin and carboxy methyl cellulose concentrations) was studied on five responses: yield, morphology, dissolution rate at 30 and 60 min, and encapsulation efficiency of the microspheres. During the screening phase, the factors were evaluated in order to identify those which exert a significant effect. Simultaneous multiple response optimizations were then used to find out experimental conditions where the system shows the most adequate results. The optimal conditions were found to be: chitosan concentration, 1.00% w/v, pectin concentration 0.10% w/v and carboxymethylcellulose concentration 0.20% w/v. The bioavailability of the loaded drug in the optimized microspheres was evaluated in Wistar rats which showed an area under curve (AUC) almost 10 times higher than the pure drug.
Palabras clave: Albendazole , Biomaterials , Microspheres , Oral Drug Release , Spray Drying
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/6846
URL: http://www.tandfonline.com/doi/abs/10.3109/03639045.2013.858737?journalCode=iddi
DOI: http://dx.doi.org/10.3109/03639045.2013.858737
URL: http://dx.doi.org/ 10.3109/03639045.2013.858737
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Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO
Citación
García, Agustina; Olivieri, Alejandro Cesar; Piccirilli, Gisela Noemi; Mamprin, María Eugenia; Olivieri, Alejandro Cesar; et al.; Spray drying formulation of albendazole microspheres by experimental design. In vitro–in vivo studies; Taylor & Francis; Drug Development and Industrial Pharmacy; 41; 2; 11-2013; 244-252
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