Artículo
Regulating the regulators: Serine/arginine-rich proteins under scrutiny
Risso, Guillermo
; Pelisch, Federico Gaston
; Quaglino, Ana
; Pozzi, María Berta
; Srebrow, Anabella
Fecha de publicación:
10/2012
Editorial:
John Wiley & Sons Inc
Revista:
IUBMB Life
ISSN:
1521-6543
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Serine/arginine-rich (SR) proteins are among the most studied splicing regulators. They constitute a family of evolutionarily conserved proteins that, apart from their initially identified and deeply studied role in splicing regulation, have been implicated in genome stability, chromatin binding, transcription elongation, mRNA stability, mRNA export and mRNA translation. Remarkably, this list of SR protein activities seems far from complete, as unexpected functions keep being unraveled. An intriguing aspect that awaits further investigation is how the multiple tasks of SR proteins are concertedly regulated within mammalian cells. In this article, we first discuss recent findings regarding the regulation of SR protein expression, activity and accessibility. We dive into recent studies describing SR protein auto-regulatory feedback loops involving different molecular mechanisms such asunproductive splicing, microRNA-mediated regulation and translational repression. In addition, we take into account another step of regulation of SR proteins, presenting new findings about a variety of post-translational modifications by proteomics approaches and how some of these modifications can regulate SR protein sub-cellular localization or stability. Towards the end, we focus in two recently revealed functions of SR proteins beyond mRNA biogenesis and metabolism, the regulation of micro-RNA processing and the regulation of small ubiquitin-like modifier (SUMO) conjugation.
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Articulos(OCA CIUDAD UNIVERSITARIA)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Citación
Risso, Guillermo; Pelisch, Federico Gaston; Quaglino, Ana; Pozzi, María Berta; Srebrow, Anabella; Regulating the regulators: Serine/arginine-rich proteins under scrutiny; John Wiley & Sons Inc; IUBMB Life; 64; 10; 10-2012; 809-816
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