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Artículo

Fructose rich diet-induced high plasminogen activator inhibitor-1 (PAI-1) production in the adult female rat: Protective effect of progesterone

Castrogiovanni, Daniel CayetanoIcon ; Alzamendi, AnaIcon ; Ongaro Gambino, LuisinaIcon ; Giovambattista, AndresIcon ; Gaillard, Rolf C.; Spinedi, Eduardo JulioIcon
Fecha de publicación: 08/2012
Editorial: MDPI
Revista: Nutrients
ISSN: 2072-6643
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Nutrición, Dietética

Resumen

The effect of progesterone (P4) on fructose rich diet (FRD) intake-induced metabolic, endocrine and parametrial adipose tissue (PMAT) dysfunctions was studied in the adult female rat. Sixty day-old rats were i.m. treated with oil alone (control, CT) or containing P4 (12 mg/kg). Rats ate Purina chow-diet ad libitum throughout the entire experiment and, between 100 and 120 days of age drank ad libitum tap water alone (normal diet; CT-ND and P4-ND) or containing fructose (10% w/v; CT-FRD and P4-FRD). At age 120 days, animals were subjected to a glucose tolerance test or decapitated. Plasma concentrations of various biomarkers and PMAT gene abundance were monitored. P4-ND (vs. CT-ND) rats showed elevated circulating levels of lipids. CT-FRD rats displayed high (vs. CT-ND) plasma concentrations of lipids, leptin, adiponectin and plasminogen activator inhibitor-1 (PAI-1). Lipidemia and adiponectinemia were high (vs. P4-ND) in P4-FRD rats. Although P4 failed to prevent FRD-induced hyperleptinemia, it was fully protective on FRD-enhanced plasma PAI-1 levels. PMAT leptin and adiponectin mRNAs were high in CT-FRD and P4-FRD rats. While FRD enhanced PMAT PAI-1 mRNA abundance in CT rats, this effect was absent in P4 rats. Our study supports that a preceding P4-enriched milieu prevented the enhanced prothrombotic risk induced by FRD-elicited high PAI-1 production.
Palabras clave: Adipokines , Allostasis , Glucose Tolerance , High Carbohydrate Diet , Insulin
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/68117
URL: https://www.mdpi.com/2072-6643/4/8/1137
DOI: http://dx.doi.org/10.3390/nu4081137
Colecciones
Articulos(IMBICE)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA CELULAR (I)
Citación
Castrogiovanni, Daniel Cayetano; Alzamendi, Ana; Ongaro Gambino, Luisina; Giovambattista, Andres; Gaillard, Rolf C.; et al.; Fructose rich diet-induced high plasminogen activator inhibitor-1 (PAI-1) production in the adult female rat: Protective effect of progesterone; MDPI; Nutrients; 4; 8; 8-2012; 1137-1150
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