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Artículo

Structure and properties of biocompatible poly(glycerol adipate) elastomers modified with ethylene glycol

Navarro, LucilaIcon ; Ceaglio, Natalia AnaliaIcon ; Rintoul, IgnacioIcon
Fecha de publicación: 08/2017
Editorial: Nature Publishing Group
Revista: Polymer Journal
ISSN: 0032-3896
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Biotecnologías de la Salud

Resumen

Polyesters poly(glycerol adipate)s or PGAs were prepared through a catalyst-free polycondensation reaction involving different proportions of adipic acid and glycerol. Additionally, another set of PGAs was formulated by adding ethylene glycol to the reaction mixture, creating three PGA-co-ethylene glycols of different ethylene glycol-to-glycerol ratios. All prepolymers were chemically crosslinked into elastomeric films according to specific experimental conditions. A full characterization of elastomers revealed an ease of tunability according to monomer ratios and curing conditions. Mechanical properties presented a variety of Young's modulus values ranging from 0.07 to 8.33 MPa. Within this range, a number of Young's modulus values of soft tissues can be included. Moreover, a cytotoxicity analysis performed on embryonic mouse fibroblasts (NIH/3T3) showed an absence of cytotoxicity and good adherence over all PGA and PGA-co-ethylene glycol elastomers. In addition, fibroblasts underwent a differentiation process into neuron-like cells, thus exhibiting excellent potential for soft tissue engineering.
Palabras clave: Poly(Glycerol Adipate) Elastomers , Ethylene Glycol , Biocompatible Materials , Soft Tissue Engineering
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/68012
URL: https://www.nature.com/articles/pj201730
DOI: http://dx.doi.org/10.1038/pj.2017.30
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Articulos(CCT - SANTA FE)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SANTA FE
Citación
Navarro, Lucila; Ceaglio, Natalia Analia; Rintoul, Ignacio; Structure and properties of biocompatible poly(glycerol adipate) elastomers modified with ethylene glycol; Nature Publishing Group; Polymer Journal; 49; 8; 8-2017; 625-632
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