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dc.contributor.author
Caracciolo, Pablo Christian
dc.contributor.author
de Queiroz, A. A. A.
dc.contributor.author
Higa, O. Z.
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Buffa, Fabián Alejandro
dc.contributor.author
Abraham, Gustavo Abel
dc.date.available
2019-01-14T18:11:31Z
dc.date.issued
2008-07
dc.identifier.citation
Caracciolo, Pablo Christian; de Queiroz, A. A. A.; Higa, O. Z.; Buffa, Fabián Alejandro; Abraham, Gustavo Abel; Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties; Elsevier; Acta Biomaterialia; 4; 4; 7-2008; 976-988
dc.identifier.issn
1742-7061
dc.identifier.uri
http://hdl.handle.net/11336/67983
dc.description.abstract
This work describes the preparation, physicochemical characterization, mechanical properties and in vitro biological properties of two bioresorbable aliphatic segmented poly(esterurethane urea)s (SPEUU) based on poly(ε-caprolactone) diol (PCL diol), 1,6-hexamethylene diisocyanate and two novel urea-diol chain extenders. To strengthen the interactions through hydrogen bonding in the hard segments of SPEUU, novel chain extenders containing urea groups were synthesized and used in the SPEUU formulation. The different chemical structures of the chain extenders modulated the phase separation of soft and hard segments, as demonstrated by the thermal behavior. The hard segment association was enhanced using a diurea-diol chain extender. The biological interactions between the obtained materials and blood were studied by in vitro methods. Research on the protein adsorption, platelet adhesion and thrombus formation is presented. Studies of protein adsorption onto polymeric surfaces showed that SPEUU adsorbed more albumin than fibrinogen. Studies on platelet adhesion and thrombus formation of SPEUU-coated coverslips indicated the antithrombogenic behavior of these surfaces. The synthesized SPEUU revealed no signs of cytotoxicity to Chinese hamster ovary cells, showing satisfactory cytocompatibility.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Blood Compatibility
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Chain Extender
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Cytotoxicity
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Segmented Poly(Esterurethane Urea)S
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Biotecnología Industrial
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Biotecnología Industrial
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-09T14:40:16Z
dc.journal.volume
4
dc.journal.number
4
dc.journal.pagination
976-988
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
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Fil: de Queiroz, A. A. A.. Universidade Federal de Itajubá; Brasil
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Fil: Higa, O. Z.. Universidade Federal de Itajubá; Brasil
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Fil: Buffa, Fabián Alejandro. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
dc.journal.title
Acta Biomaterialia
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1742706108000494
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.actbio.2008.02.016
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