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dc.contributor.author Caffaro, Pedro Alejandro
dc.contributor.author Suárez, Luis Daniel
dc.contributor.author Blake, Mariano Guillermo
dc.contributor.author Delorenzi, Alejandro
dc.date.available 2019-01-11T13:57:48Z
dc.date.issued 2012-10
dc.identifier.citation Caffaro, Pedro Alejandro; Suárez, Luis Daniel; Blake, Mariano Guillermo; Delorenzi, Alejandro; Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 98; 3; 10-2012; 235-245
dc.identifier.issn 1074-7427
dc.identifier.uri http://hdl.handle.net/11336/67917
dc.description.abstract The reconsolidation hypothesis has challenged the traditional view of fixed memories after consolidation. Reconsolidation studies have disclosed that the mechanisms mediating memory retrieval and the mechanisms that underlie the behavioral expression of memory can be dissociated, offering a new prospect for understanding the nature of experimental amnesia. The muscarinic antagonist scopolamine has been used for decades to induce experimental amnesias The goal of the present study is to determine whether the amnesic effects of scopolamine are due to storage (or retrieval) deficits or, alternatively, to a decrease in the long-term memory expression of a consolidated long-term memory. In the crab Chasmagnathus memory model, we found that scopolamine-induced amnesia can be reverted by facilitation after reminder presentation. This recovery of memory expression was reconsolidation specific since a reminder that does not triggers reconsolidation process did not allow the recovery. A higher dose (5 μg/g) of scopolamine induced an amnesic effect that could not be reverted through reconsolidation, and thus it can be explained as an interference with memory storage and/or retrieval mechanisms. These results, showing that an effective amnesic dose of scopolamine (100. ng/g) negatively modulates long-term memory expression but not memory storage in the crab Chasmagnathus, are consistent with the concept that dissociable processes underlie the mechanisms mediating memory reactivation and the behavioral expression of memory. © 2012 Elsevier Inc.
dc.format application/pdf
dc.language.iso eng
dc.publisher Academic Press Inc Elsevier Science
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject AMNESIA
dc.subject CHASMAGNATHUS
dc.subject MEMORY EXPRESSION
dc.subject RECONSOLIDATION
dc.subject RETRIEVAL
dc.subject SCOPOLAMINE
dc.subject.classification Otras Ciencias Biológicas
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2019-01-02T19:55:09Z
dc.journal.volume 98
dc.journal.number 3
dc.journal.pagination 235-245
dc.journal.pais Estados Unidos
dc.journal.ciudad San Diego
dc.description.fil Fil: Caffaro, Pedro Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil Fil: Suárez, Luis Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil Fil: Blake, Mariano Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
dc.description.fil Fil: Delorenzi, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.journal.title Neurobiology of Learning and Memory
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1074742712001086
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.nlm.2012.08.003
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)