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dc.contributor.author
Daverio, Maria Silvana
dc.contributor.author
Di Rocco, Florencia
dc.contributor.author
Vidal Rioja, Lidia
dc.date.available
2019-01-09T20:33:43Z
dc.date.issued
2012-04
dc.identifier.citation
Daverio, Maria Silvana; Di Rocco, Florencia; Vidal Rioja, Lidia; The llama (Lama glama) growth hormone gene: Sequence, organization and SNP identification; Elsevier Science; Journal of Small Ruminant Research; 103; 2-3; 4-2012; 108-111
dc.identifier.issn
0921-4488
dc.identifier.uri
http://hdl.handle.net/11336/67865
dc.description.abstract
Growth hormone (GH) is a peptide hormone found in most vertebrates, which has important effects on the muscular development during growth as well as on the production and composition of milk during lactation. Here, we report the sequence and organization of the GH gene, its promoter region and several single nucleotide polymorphisms (SNPs) in the llama (Lama glama), a domestic camelid from South America. Like in other mammals, the GH gene in the llama is organized in five exons separated by four introns. Comparison of its coding sequence with that of other cetartiodactyl species showed identities that ranged from 90.3% when compared with that of sheep to 99.1% when compared with that of camel (Camelus dromedarius). Introns were less conserved, particularly Intron C, which in the llama was found to be considerably shorter than in other species. In the promoter region, the TATA box showed a T/C substitution in the first base, also present in the camel. Other regulatory elements of the promoter region are fully conserved, except Sp1, CRE, and the proximal Pit-1 element, which present substitutions with respect to other cetartiodactyl species. Sequencing of the GH gene in a sample of 10 llamas allowed us to identify 15 SNPs, mainly located in non-coding regions. However, three of them were found in the promoter and the 5'-UTR of Exon 1, regions involved in transcription and translation processes. Moreover, in other species, intronic polymorphisms were found to be associated with growth and carcass traits. Therefore, further studies in llama herds will be necessary to infer the role of the polymorphisms found in this paper. © 2011 Elsevier B.V.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Growth Hormone
dc.subject
Llama
dc.subject
Nucleotide Sequence
dc.subject
Polymorphisms
dc.subject
Promoter
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
The llama (Lama glama) growth hormone gene: Sequence, organization and SNP identification
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-02T19:32:41Z
dc.journal.volume
103
dc.journal.number
2-3
dc.journal.pagination
108-111
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Daverio, Maria Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
dc.description.fil
Fil: Di Rocco, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
dc.description.fil
Fil: Vidal Rioja, Lidia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
dc.journal.title
Journal of Small Ruminant Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.smallrumres.2011.08.008
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0921448811003038
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