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dc.contributor.author
Perello, Mario
dc.contributor.author
Scott, Michael M.
dc.contributor.author
Sakata, Ichiro
dc.contributor.author
Lee, Charlotte E.
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Chuang, Jen Chieh
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Osborne Lawrence, Sherri
dc.contributor.author
Rovinsky, Sherry A.
dc.contributor.author
Elmquist, Joel K.
dc.contributor.author
Zigman, Jeffrey M.
dc.date.available
2019-01-09T20:11:49Z
dc.date.issued
2012-02
dc.identifier.citation
Perello, Mario; Scott, Michael M.; Sakata, Ichiro; Lee, Charlotte E.; Chuang, Jen Chieh; et al.; Functional implications of limited leptin receptor and ghrelin receptor coexpression in the brain; Wiley-liss, Div John Wiley & Sons Inc; Journal Of Comparative Neurology; 520; 2; 2-2012; 281-294
dc.identifier.issn
0021-9967
dc.identifier.uri
http://hdl.handle.net/11336/67848
dc.description.abstract
The hormones leptin and ghrelin act in apposition to one another in the regulation of body weight homeostasis. Interestingly, both leptin receptor expression and ghrelin receptor expression have been observed within many of the same nuclei of the central nervous system (CNS), suggesting that these hormones may act on a common population of neurons to produce changes in food intake and energy expenditure. In the present study we explored the extent of this putative direct leptin and ghrelin interaction in the CNS and addressed the question of whether a loss of ghrelin signaling would affect sensitivity to leptin. Using histological mapping of leptin receptor and ghrelin receptor expression, we found that cells containing both leptin receptors and ghrelin receptors are mainly located in the medial part of the hypothalamic arcuate nucleus. In contrast, coexpression was much less extensive elsewhere in the brain. To assess the functional consequences of this observed receptor distribution, we explored the effect of ghrelin receptor deletion on leptin sensitivity. In particular, the responses of ad libitum-fed, diet-induced obese and fasted mice to the anorectic actions of leptin were examined. Surprisingly, we found that deletion of the ghrelin receptor did not affect the sensitivity to exogenously administrated leptin. Thus, we conclude that ghrelin and leptin act largely on distinct neuronal populations and that ghrelin receptor deficiency does not affect sensitivity to the anorexigenic and body weight-lowering actions of leptin. © 2011 Wiley Periodicals, Inc.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, Div John Wiley & Sons Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Arcuate Nucleus
dc.subject
Food Intake
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Ghsr
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Leprb
dc.subject
Obesity
dc.subject.classification
Inmunología
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Functional implications of limited leptin receptor and ghrelin receptor coexpression in the brain
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-02T19:32:15Z
dc.journal.volume
520
dc.journal.number
2
dc.journal.pagination
281-294
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Perello, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Texas Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Scott, Michael M.. University of Texas Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Sakata, Ichiro. University of Texas Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Lee, Charlotte E.. University of Texas Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Chuang, Jen Chieh. University of Texas Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Osborne Lawrence, Sherri. University of Texas Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Rovinsky, Sherry A.. University of Texas Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Elmquist, Joel K.. University of Texas Southwestern Medical Center; Estados Unidos
dc.description.fil
Fil: Zigman, Jeffrey M.. University of Texas Southwestern Medical Center; Estados Unidos
dc.journal.title
Journal Of Comparative Neurology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1002/cne.22690
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/cne.22690
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